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Literature summary for 1.1.2.4 extracted from

  • Olson, S.T.; Massey, V.; Ghisla, S.; Whitfield, C.D.
    Suicide inactivation of the flavoenzyme D-lactate dehydrogenase by alpha-hydroxybutynoate (1979), Biochemistry, 18, 4724-4731.
    View publication on PubMed
Search for more literature for 1.1.2.4

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxybutanoate irreversible inactivation, modification of FAD Megasphaera elsdenii
2-oxobutanoate inactivation under anaerobic conditions Megasphaera elsdenii

Metals/Ions

Metals/Ions Comment Organism Structure
ferricyanide can substitute for cytochrome c Megasphaera elsdenii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-lactate + 2 ferricytochrome c Megasphaera elsdenii
-
 pyruvate + ferrocytochrome c
-
 ?

Organism

Organism UniProt Comment Textmining
Megasphaera elsdenii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-lactate + 2 ferricytochrome c
-
 Megasphaera elsdenii pyruvate + ferrocytochrome c
-
 ?
(R)-lactate + ferricytochrome c
-
 Megasphaera elsdenii pyruvate + ferrocytochrome c
-
 ?
D-2-hydroxybutyrate + cytochrome c reversible under anaerobic conditions Megasphaera elsdenii 2-oxobutanoate + ferrocytochrome c
-
 r

Cofactor

Cofactor Comment Organism Structure
2,6-dichlorophenolindophenol can substitute for cytochrome c Megasphaera elsdenii
FAD
-
 Megasphaera elsdenii