Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glycerate + NAD+ | Homo sapiens | - |
hydroxypyruvate + NADH + H+ | - |
? | |
glycolate + NADP+ | Homo sapiens | - |
glyoxylate + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UBQ7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
HT-29 cell | cultured with tumor necrosis factor alpha | Homo sapiens | - |
intestinal epithelial cell | - |
Homo sapiens | - |
intestine | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glycerate + NAD+ | - |
Homo sapiens | hydroxypyruvate + NADH + H+ | - |
? | |
glycolate + NADP+ | - |
Homo sapiens | glyoxylate + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
glyoxylate reductase/hydroxypyruvate reductase | - |
Homo sapiens |
GRHPR | - |
Homo sapiens |
GRHPR | bifunctional enzyme with glyoxylate reductase and hydroxypyruvate reductase activities | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | upregulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) by trinitrobenzenesulphonic acid, which induces experimental colitis and intestinal epithelial cell apoptosis | up |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deficiency is the underlying cause of primary hyperoxaluria type 2 (PH2) and leads to increased urinary oxalate levels, formation of kidney stones and renal failure. Upregulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis, the phenomenon also occurs in patients with Crohn's disease. Overexpression of GRHPR is accompanied by active caspase-3 and cleaved poly ADP-ribose polymerase (PARP) accumulation. Knockdown of GRHPR inhibits the accumulation of active caspase-3 and cleaved PARP in TNF-alpha treated HT-29 cells | Homo sapiens |
physiological function | upregulation of glyoxylate reductase/hydroxypyruvate reductase is associated with intestinal epithelial cells apoptosis in trinitrobenzenesulfonic acid-induced colitis | Homo sapiens |
physiological function | human glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is a D-2 hydroxy-acid dehydrogenase that plays a critical role in the removal of the metabolic by-product glyoxylate from the liver | Homo sapiens |