Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli strain JM109 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Homo sapiens | |
0.011 | - |
NADPH | 37°C | Homo sapiens | |
0.011 | - |
NADPH | pH 7.5, 37°C, recombinant enzyme | Homo sapiens | |
0.058 | - |
Hydroxypyruvate | 37°C, cofactor: NAPDH | Homo sapiens | |
0.058 | - |
Hydroxypyruvate | pH 7.5, 37°C, recombinant enzyme, with NADPH | Homo sapiens | |
0.19 | - |
Hydroxypyruvate | 37°C, cofactor: NADH | Homo sapiens | |
0.19 | - |
Hydroxypyruvate | pH 7.5, 37°C, recombinant enzyme, with NADH | Homo sapiens | |
0.24 | - |
glyoxylate | 37°C, cofactor: NADPH | Homo sapiens | |
0.24 | - |
glyoxylate | pH 7.5, 37°C, recombinant enzyme, with NADPH | Homo sapiens | |
1 | - |
glyoxylate | 37°C, cofactor: NADH | Homo sapiens | |
1 | - |
glyoxylate | pH 7.5, 37°C, recombinant enzyme, with NADH | Homo sapiens | |
2.42 | - |
NADH | 37°C | Homo sapiens | |
2.42 | - |
NADH | pH 7.5, 37°C, recombinant enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glyoxylate + NAD(P)H | Homo sapiens | the enzyme plays a protective role in detoxification of glyoxylate | glycolate + NAD(P)+ | - |
? | |
hydroxypyruvate + NAD(P)H | Homo sapiens | - |
D-glycerate + NAD(P)+ + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
recombinant | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glyoxylate + NAD(P)H | - |
Homo sapiens | glycolate + NAD(P)+ | - |
? | |
glyoxylate + NAD(P)H | the enzyme plays a protective role in detoxification of glyoxylate | Homo sapiens | glycolate + NAD(P)+ | - |
? | |
glyoxylate + NADH | affinity for NADPH is lower than affinity for NADH | Homo sapiens | glycolate + NAD+ | - |
? | |
glyoxylate + NADPH | - |
Homo sapiens | glycolate + NADP+ | - |
? | |
hydroxypyruvate + NAD(P)H | - |
Homo sapiens | D-glycerate + NAD(P)+ + H+ | - |
? | |
hydroxypyruvate + NAD(P)H | preferred substrate | Homo sapiens | D-glycerate + NAD(P)+ + H+ | - |
? | |
hydroxypyruvate + NADH | affinity for NADPH is lower than affinity for NADH | Homo sapiens | D-glycerate + NAD+ | - |
? | |
hydroxypyruvate + NADPH | - |
Homo sapiens | D-glycerate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glyoxylate reductase | - |
Homo sapiens |
GR/HPR | - |
Homo sapiens |
GRHPR | - |
Homo sapiens |
More | the enzyme shows bifunctionality also performing the reaction of hydroxypyruvate reductase, EC 1.1.1.81 | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
27 | - |
glyoxylate | 37°C, cofactor: NADPH | Homo sapiens | |
27 | - |
glyoxylate | pH 7.5, 37°C, recombinant enzyme, with NADPH | Homo sapiens | |
38 | - |
Hydroxypyruvate | 37°C, cofactor: NAPDH | Homo sapiens | |
38 | - |
Hydroxypyruvate | pH 7.5, 37°C, recombinant enzyme, with NADPH | Homo sapiens | |
65 | - |
Hydroxypyruvate | 37°C, cofactor: NADH | Homo sapiens | |
65 | - |
Hydroxypyruvate | pH 7.5, 37°C, recombinant enzyme, with NADH | Homo sapiens | |
67 | - |
glyoxylate | 37°C, cofactor: NADH | Homo sapiens | |
67 | - |
glyoxylate | pH 7.5, 37°C, recombinant enzyme, with NADH | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens | |
NADH | higher affinity for NADPH | Homo sapiens | |
NADPH | preferred cofactor | Homo sapiens | |
NADPH | lower affinity for NADH | Homo sapiens |