Literature summary for 1.1.1.64 extracted from

Legeza, B.; Balazs, Z.; Nashev, L.G.; Odermatt, A.
The microsomal enzyme 17beta-hydroxysteroid dehydrogenase 3 faces the cytoplasm and uses NADPH generated by glucose-6-phosphate dehydrogenase (2013), Endocrinology, 154, 205-213.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293 cell	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
additional information	isoform 17beta-HSD3 shows a cytoplasmic orientation and dependence on glucose-6-phosphate dehydrogenase-generated NADPH	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P37058	-	-

General Information

General Information	Comment	Organism
physiological function	isoform 17beta-HSD3-dependent reduction of 4-androstene-3,17-dione is affected by neither coexpression with 11beta-HSD1, EC 1.1.1.146, nor overexpression or knock-down of hexose-6-phosphate dehydrogenase. Knock-down of glucose-6-phosphate dehydrogenase decreases 17beta-HSD3 activity, indicating dependence on cytoplasmic NADPH. Cytoplasmic orientation of isoform 17beta-HSD3 and dependence on glucose-6-phosphate dehydrogenase-generated NADPH explain the lack of a direct functional coupling with the luminal 11beta-HSD1-mediated glucocorticoid metabolism	Homo sapiens

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Release 2023.1 (January 2023)