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Literature summary for 1.1.1.64 extracted from

  • Yuan, K.; Zhao, B.; Li, X.W.; Hu, G.X.; Su, Y.; Chu, Y.; Akingbemi, B.T.; Lian, Q.Q.; Ge, R.S.
    Effects of phthalates on 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 activities in human and rat testes (2012), Chem. Biol. Interact., 195, 180-188.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bis(2-butoxyethyl) phthalate potent inhibitor of testis 17beta-hydroxysteroid dehydrogenase type 3, additionally inhibits 3beta-hydroxysteriod dehydrogenase Homo sapiens
bis(2-butoxyethyl) phthalate potent inhibitor of testis 17beta-hydroxysteroid dehydrogenase type 3, additionally inhibits 3beta-hydroxysteriod dehydrogenase Rattus norvegicus
dicyclohexyl phthalate potent inhibitor of testis 17beta-hydroxysteroid dehydrogenase type 3, additionally inhibits 3beta-hydroxysteriod dehydrogenase Homo sapiens
dicyclohexyl phthalate potent inhibitor of testis 17beta-hydroxysteroid dehydrogenase type 3, additionally inhibits 3beta-hydroxysteriod dehydrogenase Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens P37058
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Rattus norvegicus
-
testis
-
Homo sapiens
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0055
-
dicyclohexyl phthalate isoform 17beta-hydroxysteroid dehydrogenase type 3, pH 7.4, 37°C Homo sapiens
0.0085
-
dicyclohexyl phthalate isoform 17beta-hydroxysteroid dehydrogenase type 3, pH 7.4, 37°C Rattus norvegicus
0.0165
-
dicyclohexyl phthalate isoform 3beta-hydroxysteriod dehydrogenase, pH 7.4, 37°C Rattus norvegicus
0.017
-
bis(2-butoxyethyl) phthalate isoform 17beta-hydroxysteroid dehydrogenase type 3 , pH 7.4, 37°C Homo sapiens
0.0219
-
dicyclohexyl phthalate isoform 3beta-hydroxysteriod dehydrogenase, pH 7.4, 37°C Homo sapiens
0.0285
-
bis(2-butoxyethyl) phthalate isoform 17beta-hydroxysteroid dehydrogenase type 3 , pH 7.4, 37°C Rattus norvegicus
0.0335
-
bis(2-butoxyethyl) phthalate isoform 3beta-hydroxysteriod dehydrogenase , pH 7.4, 37°C Homo sapiens
0.05
-
bis(2-butoxyethyl) phthalate isoform 3beta-hydroxysteriod dehydrogenase , pH 7.4, 37°C Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0082
-
isoform 17beta-hydroxysteroid dehydrogenase type 3, pH 7.4, 37°C Homo sapiens dicyclohexyl phthalate
0.0233
-
isoform 17beta-hydroxysteroid dehydrogenase type 3 , pH 7.4, 37°C Homo sapiens bis(2-butoxyethyl) phthalate
0.0247
-
isoform 3beta-hydroxysteriod dehydrogenase, pH 7.4, 37°C Rattus norvegicus dicyclohexyl phthalate
0.0255
-
isoform 3beta-hydroxysteriod dehydrogenase, pH 7.4, 37°C Homo sapiens dicyclohexyl phthalate
0.0302
-
isoform 17beta-hydroxysteroid dehydrogenase type 3 , pH 7.4, 37°C Rattus norvegicus bis(2-butoxyethyl) phthalate
0.0503
-
isoform 3beta-hydroxysteriod dehydrogenase , pH 7.4, 37°C Homo sapiens bis(2-butoxyethyl) phthalate
0.0825
-
isoform 3beta-hydroxysteriod dehydrogenase , pH 7.4, 37°C Rattus norvegicus bis(2-butoxyethyl) phthalate
0.09
-
isoform 17beta-hydroxysteroid dehydrogenase type 3, pH 7.4, 37°C Rattus norvegicus dicyclohexyl phthalate