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Literature summary for 1.1.1.64 extracted from

  • Mindnich, R.; Haller, F.; Halbach, F.; Moeller, G.; Hrabe de Angelis, M.; Adamski, J.
    Androgen metabolism via 17beta-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme (2005), J. Mol. Endocrinol., 35, 305-316.
    View publication on PubMed
Search for more literature for 1.1.1.64

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Danio rerio 5783
-

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain low activity in both sexes Danio rerio
-
embryo during embryogenesis the enzyme is present from the sphere stage until hatching Danio rerio
-
eye
-
 Danio rerio
-
heart expression in male, hardly detectable in female Danio rerio
-
intestine expression in male, hardly detectable in female Danio rerio
-
kidney expression in male, hardly detectable in female Danio rerio
-
liver
-
 Danio rerio
-
muscle
-
 Danio rerio
-
skin expression in male, hardly detectable in female Danio rerio
-
spleen expression in male, hardly detectable in female Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-hydroxy-androstenedione + NADPH
-
 Homo sapiens 11beta-hydroxy-testosterone
-
 ?
11-hydroxy-androstenedione + NADPH
-
 Danio rerio 11beta-hydroxy-testosterone
-
 ?
11-ketoandrostenedione + NADPH
-
 Homo sapiens 11-ketotestosterone + NADP+
-
 ?
11-ketoandrostenedione + NADPH
-
 Danio rerio 11-ketotestosterone + NADP+
-
 ?
androstanedione + NADPH
-
 Homo sapiens dihydrotestosterone + NADP+
-
 ?
androstenedione + NADPH + H+
-
 Homo sapiens testosterone + NADP+
-
 r
androstenedione + NADPH + H+
-
 Danio rerio testosterone + NADP+
-
 r
androsterone + NADPH + H+
-
 Homo sapiens androstane-3beta,17beta-diol + NADP+
-
 ?
dehydroepiandrosterone + NADPH
-
 Homo sapiens androst-5-en-3beta,17beta-diol + NADP+
-
 ?
dehydroepiandrosterone + NADPH
-
 Danio rerio androst-5-en-3beta,17beta-diol + NADP+
-
 ?
epiandrosterone + NADPH
-
 Homo sapiens androstane-3beta,17beta-diol + NADP+
-
 ?
epiandrosterone + NADPH
-
 Danio rerio androstane-3beta,17beta-diol + NADP+
-
 ?
testosterone + NAD+ NAD+ shows 20% of the activity with NADP+ Homo sapiens androstenedione + NADH
-
 ir
testosterone + NAD+ NAD+ shows ess than 10% of the activity with NADP+ Danio rerio androstenedione + NADH
-
 ir

Synonyms

Synonyms Comment Organism
17beta-HSD 3
-
 Homo sapiens
17beta-HSD 3
-
 Danio rerio
17beta-hydroxysteroid dehydrogenase type 3
-
 Homo sapiens
17beta-hydroxysteroid dehydrogenase type 3
-
 Danio rerio

Cofactor

Cofactor Comment Organism Structure
NAD+ 20% of the activity with NADP+, cosubstrate: testosterone Homo sapiens
NAD+ less than 10% of the activity with NADP+, cosubstrate: testosterone Danio rerio
NADP+
-
 Homo sapiens
NADP+
-
 Danio rerio
NADPH no activity with NADH Homo sapiens
NADPH no activity with NADH Danio rerio