Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.64 extracted from

  • Andersson, S.; Geissler, W.M.; Wu, L.; Davis, D.L.; Grumbach, M.M.; New, M.I.; Schwarz, H.P.; Blethen, S.L.; Mendoca.B.B.; Bloise, W.; Witchel, S.F.; Cutler, G.B.; Griffin, J.E.; Wilson, J.D.; Russell, D.W.
    Molecular genetics and pathophysiology of 17beta-hydroxysteroid dehydrogenase 3 deficiency (1996), J. Clin. Endocrinol., 81, 130-136.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
17beta-hydroxysteroid dehydrogenase 3, expressed in human embryonic kidney 293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E215D inactive enzyme Homo sapiens
F208I inactive enzyme Homo sapiens
P282L inactive enzyme Homo sapiens
R80Q 20% residual activity Homo sapiens
S65L inactive enzyme Homo sapiens
V205E inactive enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17beta-estradiol + NADP+ Homo sapiens
-
estrone + NADPH
-
r
testosterone + NADP+ Homo sapiens
-
androst-4-ene-3,17-dione + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NADP+
-
Homo sapiens estrone + NADPH
-
r
testosterone + NADP+
-
Homo sapiens androst-4-ene-3,17-dione + NADPH + H+
-
r

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens