Cloned (Comment) | Organism |
---|---|
85% amino acid sequence homology with human carbonyl reductase | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
androstan-3alpha,17beta-diol + NAD+ = 17beta-hydroxyandrostan-3-one + NADH + H+ | exhibits carbonyl reductase-like activity, 85% amino acid sequence homology with human carbonyl reductase | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.038 | - |
NADPH, phenylglyoxal | Sus scrofa |
0.039 | - |
NADPH, 5alpha-dihydrotestosterone | Sus scrofa |
0.039 | - |
NADPH, 5beta-dihydrotestosterone | Sus scrofa |
0.042 | - |
NADPH, cyclohexanone | Sus scrofa |
0.043 | - |
NADPH, 4-nitrobenzaldehyde | Sus scrofa |
0.045 | - |
NADPH, camphorquinone | Sus scrofa |
0.123 | - |
NADPH, methylglyoxal | Sus scrofa |
0.157 | - |
NADPH, phenanthrenequinone | Sus scrofa |
0.167 | - |
NADPH, hydrindantin | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-hydroxyprogesterone + NADPH + H+ | - |
Sus scrofa | 17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+ | - |
? | |
4-nitrobenzaldehyde + NADPH | - |
Sus scrofa | ? | - |
? | |
5alpha-androstan-17beta-ol-3-one + NAD(P)H + H+ | i.e. 5alpha-dihydrotestosterone | Sus scrofa | 5alpha-androstan-3alpha,17beta-diol + NAD(P)+ | - |
? | |
5beta-androstan-17beta-ol-3-one + NAD(P)H | i.e. 5beta-dihydrotestosterone | Sus scrofa | ? | - |
? | |
9,10-phenanthrenequinone + NADPH | - |
Sus scrofa | ? | - |
? | |
camphorquinone + NADPH + H+ | - |
Sus scrofa | camphorquinol + NADP+ | - |
? | |
cyclohexanone + NADPH | - |
Sus scrofa | cyclohexanol + NADP+ | - |
? | |
hydrindantin + NADPH | - |
Sus scrofa | ? | - |
? | |
methylglyoxal + NADPH | - |
Sus scrofa | ? | - |
? | |
additional information | enzyme cannot catalyze the reduction of 11-hydroxy- or 11-oxo-C21-steroids, i.e. cortisol, corticosterone, cortisone | Sus scrofa | ? | - |
? | |
phenylglyoxal + NADPH | - |
Sus scrofa | ? | - |
? | |
progesterone + NAD(P)H | - |
Sus scrofa | 20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+ | - |
? |