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Literature summary for 1.1.1.51 extracted from

  • Svegelj, M.B.; Stojan, J.; Rizner, T.L.
    The role of Ala231 and Trp227 in the substrate specificities of fungal 17beta-hydroxysteroid dehydrogenase and trihydroxynaphthalene reductase: Steroids versus smaller substrates (2012), J. Steroid Biochem. Mol. Biol., 129, 92-98.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A231Y mutation abolishes and decreases by 14.6fold the initial rates for steroid oxidation and reduction, respectively. Residue A231 allows the correct accommodation and conversion of steroids Curvularia lunata

Organism

Organism UniProt Comment Textmining
Curvularia lunata
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-estrene-17beta-ol-3-one + NADP+
-
Curvularia lunata 4-estrene-3,17-dione + NADPH
-
r
4-estrene-3,17-dione + NADPH
-
Curvularia lunata 4-estrene-17beta-ol-3-one + NADP+
-
r