Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
mitochondrion | - |
Mus musculus | 5739 | - |
additional information | the enzyme is distributed between microsomes and mitochondria, the HSD activity in microsomes is predominant throughout the follicular phase of the estrous cycle, the enzyme activity is increased in pregnant mice uteri including embryos, overview | Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + NAD+ | Mus musculus | the mitochondrial enzyme is essential for the synthesis of progesterone by corpora lutea, overview | progesterone + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
female (C3H/HeJ × 129/J)F1 (C31) hybrid mice | - |
Purification (Comment) | Organism |
---|---|
native enzyme partially from ovaries and pregnant uteri including embryos by subcellular fractionation of minced homogenates | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
corpus luteum | - |
Mus musculus | - |
ovary | - |
Mus musculus | - |
uterus | taken from 10-20 days pregnant mice for enzyme extraction including the embryo | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + NAD+ | - |
Mus musculus | progesterone + NADH + H+ | - |
? | |
pregnenolone + NAD+ | the mitochondrial enzyme is essential for the synthesis of progesterone by corpora lutea, overview | Mus musculus | progesterone + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3 beta-hydroxysteroid dehydrogenase | - |
Mus musculus |
HSD | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus |