Cloned (Comment) | Organism |
---|---|
overexpression in HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3alpha-alkylated androsterone derivatives | 17-88% inhibition at 0.003 mM, overview | Homo sapiens | |
3alpha-ether-3beta-substituted androsterone derivatives | diverse derivatives, IC50: 70-760 nM, overview | Homo sapiens | |
3beta-alkylated androsterone derivatives | IC50: 57-147 nM | Homo sapiens | |
3beta-phenylethyl-3alpha-methyl-O-androsterone | IC50: 73 nM | Homo sapiens | |
3beta-phenylethyl-androsterone | IC50: 99 nM | Homo sapiens | |
3beta-phenylmethyl-androsterone | IC50: 57 nM | Homo sapiens | |
3beta-substituted androsterone derivatives | IC50: 57-147 nM | Homo sapiens | |
additional information | synthesis, inhibitory potency, and in vivo effects of the diverse inhibitor derivatives, detailed overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
androst-4-ene-3,17-dione + NADPH | Homo sapiens | - |
testosterone + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | low enzyme expression level | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
androst-4-ene-3,17-dione + NADPH | - |
Homo sapiens | testosterone + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type 17beta-HSD | - |
Homo sapiens |
type 3 17beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000057 | - |
IC50: 57 nM | Homo sapiens | 3beta-phenylmethyl-androsterone | |
0.000057 | 0.000147 | IC50: 57-147 nM | Homo sapiens | 3beta-substituted androsterone derivatives | |
0.000057 | 0.000147 | IC50: 57-147 nM | Homo sapiens | 3beta-alkylated androsterone derivatives | |
0.00007 | 0.00076 | diverse derivatives, IC50: 70-760 nM, overview | Homo sapiens | 3alpha-ether-3beta-substituted androsterone derivatives | |
0.000073 | - |
IC50: 73 nM | Homo sapiens | 3beta-phenylethyl-3alpha-methyl-O-androsterone | |
0.000099 | - |
IC50: 99 nM | Homo sapiens | 3beta-phenylethyl-androsterone |