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Literature summary for 1.1.1.49 extracted from

  • Mercaldi, G.; Dawson, A.; Hunter, W.; Cordeiro, A.
    The structure of a Trypanosoma cruzi glucose-6-phosphate dehydrogenase reveals differences from the mammalian enzyme (2016), FEBS Lett., 590, 2776-2786.
    View publication on PubMed
Search for more literature for 1.1.1.49

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with D-glucose 6-phosphate and NADPH, hanging drop vapor diffusion method, using 30% (w/v) jeffamine ED2003 and HEPES 0.1 M pH 7.0 Trypanosoma cruzi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0474
-
 NADP+ pH and temperature not specified in the publication Trypanosoma cruzi
0.21
-
 D-glucose 6-phosphate pH and temperature not specified in the publication Trypanosoma cruzi

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57500
-
 4 * 57500, SDS-PAGE Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + NADP+ Trypanosoma cruzi
-
 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi Q4E0B2
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NADP+
-
 Trypanosoma cruzi 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
 ?

Subunits

Subunits Comment Organism
homotetramer 4 * 57500, SDS-PAGE Trypanosoma cruzi

Synonyms

Synonyms Comment Organism
G6PDH
-
 Trypanosoma cruzi
glucose-6-phosphate dehydrogenase
-
 Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Trypanosoma cruzi