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Literature summary for 1.1.1.439 extracted from
- Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine (2018), Proc. Natl. Acad. Sci. USA, 115, 3180-3185.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Saccharomyces cerevisiae | Catharanthus roseus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 15alpha-stemmadenine + NADP+ | Catharanthus roseus | - |
17-dehydrostemmadenine + NADPH + 2 H+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Catharanthus roseus | A0A2P1GIY9 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (19E)-geissoschizine + NADPH + H+ | - |
Catharanthus roseus | (16R,19E)-isositsirikine + NADP+ | - |
? | |
| 15alpha-stemmadenine + NADP+ | - |
Catharanthus roseus | 17-dehydrostemmadenine + NADPH + 2 H+ | - |
? | |
| additional information | the enzyme is unable to convert the 16S and 16R epimers of DHS to any other MIAs | Catharanthus roseus | ? | - |
- |
|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Redox2 | - |
Catharanthus roseus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | dependent on | Catharanthus roseus | |
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Release 2026.1 (March 2026)
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