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Literature summary for 1.1.1.42 extracted from

  • Karlström, M.; Stokke, R.; Steen, I.H.; Birkeland, N.K.; Ladenstein, R.
    Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability (2005), J. Mol. Biol., 345, 559-577.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures of a native enzyme at 2.2 A, a pseudo-native enzyme at 2.1 A, and of the enzyme in complex with NADP+, Ca2+ and D-isocitrate at 2.3 A Aeropyrum pernix

Organism

Organism UniProt Comment Textmining
Aeropyrum pernix Q9YE81
-
-
Aeropyrum pernix DSM 11879 Q9YE81
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
Aeropyrum pernix 2-oxoglutarate + CO2 + NADPH + H+
-
?
isocitrate + NADP+
-
Aeropyrum pernix DSM 11879 2-oxoglutarate + CO2 + NADPH + H+
-
?

Subunits

Subunits Comment Organism
homodimer
-
Aeropyrum pernix