Any feedback?
Literature summary for 1.1.1.42 extracted from
- Supramolecular complex formation and crystallization of isocitrate dehydrogenase from Thermus thermophilus HB8: preliminary studies with X-ray crystallography and atomic force microscopy (2008), Biosci. Biotechnol. Biochem., 72, 2369-2376.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli strain MV1190 | Thermus thermophilus |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| sitting and hanging drop vapour diffusion method, using 100 mM cacodylate and 1.4 M sodium acetate, 10 mM citric acid , and 10 mM MnCl2, at pH 6.5-7.8 and 25°C | Thermus thermophilus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 54200 | - |
calculated from amino acid sequence | Thermus thermophilus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thermus thermophilus | P33197 | - |
- |
| Thermus thermophilus HB8 / ATCC 27634 / DSM 579 | P33197 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Thermus thermophilus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2R,3S)-isocitrate + NADP+ | - |
Thermus thermophilus | 2-oxoglutarate + CO2 + NADPH | - |
? |  |
| (2R,3S)-isocitrate + NADP+ | - |
Thermus thermophilus HB8 / ATCC 27634 / DSM 579 | 2-oxoglutarate + CO2 + NADPH | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ICDH | - |
Thermus thermophilus |
| NAD+-dependent isocitrate dehydrogenase | - |
Thermus thermophilus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Thermus thermophilus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
