Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli or Saccharomyces cerevisiae | Mus musculus |
expression of mouse isoenzyme IDP2 in Escherichia coli or Saccharomyces cerevisiae. Mouse enzyme can compensate for loss of yeast cytosolic IDP2 and of peroxisomal IDP3IDP3. Removal of the peroxisomal targeting signal of the mouse enzyme precludes both localization in peroxisomes and compensation for loss of yeast IDP3 | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0037 | - |
NADP+ | pH 7.5, isoenzyme IDP2 | Mus musculus | |
0.0042 | - |
isocitrate | pH 7.5, isoenzyme IDP2 | Mus musculus | |
0.0056 | - |
NADP+ | pH 7.5, isoenzyme IDP1 | Mus musculus | |
0.0058 | - |
isocitrate | pH 7.5, isoenzyme IDP1 | Mus musculus | |
0.01 | - |
NADP+ | pH 7.5, isoenzyme IDP3 | Saccharomyces cerevisiae | |
0.015 | - |
isocitrate | pH 7.5, isoenzyme IDP3 | Saccharomyces cerevisiae | |
0.02 | - |
NADP+ | pH 7.5, isoenzyme IDP2 | Saccharomyces cerevisiae | |
0.03 | - |
NADP+ | pH 7.5, isoenzyme IDP1 | Saccharomyces cerevisiae | |
0.03 | - |
isocitrate | pH 7.5, isoenzyme IDP1 | Saccharomyces cerevisiae | |
0.22 | - |
isocitrate | pH 7.5, isoenzyme IDP2 | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | isoenzyme IDP1 | Mus musculus | 5739 | - |
mitochondrion | isoenzyme IDP1 | Saccharomyces cerevisiae | 5739 | - |
additional information | the mouse isoenzyme IDP2 colocalizes in cytosol and peroxisomes when expressed in yeast | Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O88844 | - |
- |
Mus musculus | P54071 | - |
- |
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae | P21954 | - |
- |
Saccharomyces cerevisiae | P41939 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | isoenzyme IDP1 | Mus musculus | - |
liver | isoenzyme IDP2 | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NADP+ | - |
Saccharomyces cerevisiae | 2-oxoglutarate + CO2 + NADPH + H+ | - |
? | |
isocitrate + NADP+ | - |
Mus musculus | 2-oxoglutarate + CO2 + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDP1 | - |
Mus musculus |
IDP1 | - |
Saccharomyces cerevisiae |
IDP2 | - |
Mus musculus |
IDP2 | - |
Saccharomyces cerevisiae |
IDP3 | - |
Saccharomyces cerevisiae |
NADP+-specific isocitrate dehydrogenase | - |
Saccharomyces cerevisiae |
NADP+-specific isocitrate dehydrogenase | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9 | more than 90% of optimal Vmax, isoenzyme IDP2 | Mus musculus |
7.5 | - |
isoenzyme IDP2 | Saccharomyces cerevisiae |
8 | - |
isoenzyme IDP1 | Saccharomyces cerevisiae |
8.5 | - |
isoenzyme IDP1 | Mus musculus |
8.5 | - |
isoenzyme IDP3 | Saccharomyces cerevisiae |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9 | pH 6.5: about 40% of maximal activity, pH 9.0: about 70% of maximal activity, isoenzyme IDP3 | Saccharomyces cerevisiae |
6.5 | 9 | pH 6.5: about 60% of maximal activity, pH 9.0: about 70% of maximal activity, isoenzyme IDP1 | Mus musculus |
7 | 9 | pH 7.0: about 60% of maximal activity, pH 9.0: about 95% of maximal activity, isoenzyme IDP1 | Saccharomyces cerevisiae |
7 | 8 | pH 7.0: about 60% of maximal activity, pH 8.0: about 40% of maximal activity, isoenzyme IDP2 | Saccharomyces cerevisiae |