Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.42 extracted from

  • Lu, Q.; Minard, K.I.; McAlister-Henn, L.
    Dual compartmental localization and function of mammalian NADP+-specific isocitrate dehydrogenase in yeast (2008), Arch. Biochem. Biophys., 472, 17-25.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli or Saccharomyces cerevisiae Mus musculus
expression of mouse isoenzyme IDP2 in Escherichia coli or Saccharomyces cerevisiae. Mouse enzyme can compensate for loss of yeast cytosolic IDP2 and of peroxisomal IDP3IDP3. Removal of the peroxisomal targeting signal of the mouse enzyme precludes both localization in peroxisomes and compensation for loss of yeast IDP3 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0037
-
NADP+ pH 7.5, isoenzyme IDP2 Mus musculus
0.0042
-
isocitrate pH 7.5, isoenzyme IDP2 Mus musculus
0.0056
-
NADP+ pH 7.5, isoenzyme IDP1 Mus musculus
0.0058
-
isocitrate pH 7.5, isoenzyme IDP1 Mus musculus
0.01
-
NADP+ pH 7.5, isoenzyme IDP3 Saccharomyces cerevisiae
0.015
-
isocitrate pH 7.5, isoenzyme IDP3 Saccharomyces cerevisiae
0.02
-
NADP+ pH 7.5, isoenzyme IDP2 Saccharomyces cerevisiae
0.03
-
NADP+ pH 7.5, isoenzyme IDP1 Saccharomyces cerevisiae
0.03
-
isocitrate pH 7.5, isoenzyme IDP1 Saccharomyces cerevisiae
0.22
-
isocitrate pH 7.5, isoenzyme IDP2 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion isoenzyme IDP1 Mus musculus 5739
-
mitochondrion isoenzyme IDP1 Saccharomyces cerevisiae 5739
-
additional information the mouse isoenzyme IDP2 colocalizes in cytosol and peroxisomes when expressed in yeast Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus O88844
-
-
Mus musculus P54071
-
-
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae P21954
-
-
Saccharomyces cerevisiae P41939
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver isoenzyme IDP1 Mus musculus
-
liver isoenzyme IDP2 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
Saccharomyces cerevisiae 2-oxoglutarate + CO2 + NADPH + H+
-
?
isocitrate + NADP+
-
Mus musculus 2-oxoglutarate + CO2 + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
IDP1
-
Mus musculus
IDP1
-
Saccharomyces cerevisiae
IDP2
-
Mus musculus
IDP2
-
Saccharomyces cerevisiae
IDP3
-
Saccharomyces cerevisiae
NADP+-specific isocitrate dehydrogenase
-
Saccharomyces cerevisiae
NADP+-specific isocitrate dehydrogenase
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 9 more than 90% of optimal Vmax, isoenzyme IDP2 Mus musculus
7.5
-
isoenzyme IDP2 Saccharomyces cerevisiae
8
-
isoenzyme IDP1 Saccharomyces cerevisiae
8.5
-
isoenzyme IDP1 Mus musculus
8.5
-
isoenzyme IDP3 Saccharomyces cerevisiae

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9 pH 6.5: about 40% of maximal activity, pH 9.0: about 70% of maximal activity, isoenzyme IDP3 Saccharomyces cerevisiae
6.5 9 pH 6.5: about 60% of maximal activity, pH 9.0: about 70% of maximal activity, isoenzyme IDP1 Mus musculus
7 9 pH 7.0: about 60% of maximal activity, pH 9.0: about 95% of maximal activity, isoenzyme IDP1 Saccharomyces cerevisiae
7 8 pH 7.0: about 60% of maximal activity, pH 8.0: about 40% of maximal activity, isoenzyme IDP2 Saccharomyces cerevisiae