Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | isozyme IDP3 is inducible by fatty acids, isozyme IDP2 by non-fermentable carbon sources, expression of isozyme IDP1 is constitutive | Saccharomyces cerevisiae |
Cloned (Comment) | Organism |
---|---|
exchange of promotors and altering of organellar targeting for expression of isozymes IDO2 and IDO3 in mitochondria, and of isozymes IDP1 and IDP3 in the cytosol, functional complementation studies using mutant strains | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
NADPH | isozyme IDP1 | Saccharomyces cerevisiae | |
0.02 | - |
NADP+ | isozyme IDP2 and IDP3 | Saccharomyces cerevisiae | |
0.03 | - |
NADP+ | isozyme IDP1 | Saccharomyces cerevisiae | |
0.03 | - |
isocitrate | isozyme IDP1 | Saccharomyces cerevisiae | |
0.04 | - |
NADPH | isozyme IDP2 | Saccharomyces cerevisiae | |
0.05 | - |
isocitrate | isozyme IDP3 | Saccharomyces cerevisiae | |
0.2 | - |
2-oxoglutarate | isozyme IDP2 | Saccharomyces cerevisiae | |
0.22 | - |
isocitrate | isozyme IDP2 | Saccharomyces cerevisiae | |
1.92 | - |
2-oxoglutarate | isozyme IDP1 | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isoyzme IDP2 | Saccharomyces cerevisiae | 5829 | - |
mitochondrion | isozyme IDP1 | Saccharomyces cerevisiae | 5739 | - |
additional information | influence of subcellular localization on isozyme activities, overview | Saccharomyces cerevisiae | - |
- |
peroxisome | isozyme IDP3 | Saccharomyces cerevisiae | 5777 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NADP+ | Saccharomyces cerevisiae | isozymes are compartment interchangeable for glutamate synthesis, although mitochondrial localization has a positive impact on this function during fermentative growth | 2-oxoglutarate + CO2 + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
3 isozymes: mitochondrial IDP1, cytosolic IDP2, peroxisomal IDP3 | - |
Oxidation Stability | Organism |
---|---|
isozyme IDP3 shows highest defense against endogeneous oxidative stress | Saccharomyces cerevisiae |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
wild-type and diverse mutant strains | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NADP+ | isozymes are compartment interchangeable for glutamate synthesis, although mitochondrial localization has a positive impact on this function during fermentative growth | Saccharomyces cerevisiae | 2-oxoglutarate + CO2 + NADPH + H+ | - |
? | |
isocitrate + NADP+ | reaction is reversible for isozymes IDP1 and IDP2 | Saccharomyces cerevisiae | 2-oxoglutarate + CO2 + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
NADP+-specific isocitrate dehydrogenase | - |
Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Saccharomyces cerevisiae | |
NADPH | - |
Saccharomyces cerevisiae |