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Literature summary for 1.1.1.42 extracted from
- Isotope effect studies of the chemical mechanism of pig heart NADP isocitrate dehydrogenase (1988), Biochemistry, 27, 2934-2943.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| oxalylglycine | - |
Sus scrofa |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | absolute requirement for divalent cations | Sus scrofa | |
| Mg2+ | absolute requirement for divalent cations | Sus scrofa | |
| Mn2+ | absolute requirement for divalent cations | Sus scrofa | |
| Ni2+ | absolute requirement for divalent cations | Sus scrofa | |
| Zn2+ | absolute requirement for divalent cations | Sus scrofa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isocitrate + NADP+ | Sus scrofa | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
pig | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-fluoroisocitrate + NADP+ | - |
Sus scrofa | 3-fluoro-2-oxoglutarate + NADPH + CO2 | - |
? | |
| 3-hydroxyisocitrate + NADP+ | - |
Sus scrofa | 3-hydroxy-2-oxoglutarate + NADPH + CO2 | - |
? | |
| isocitrate + NADP+ | - |
Sus scrofa | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Sus scrofa | |
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