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Literature summary for 1.1.1.411 extracted from

  • Zhang, C.F.; Liu, Y.P.; Wu, X.X.; Zhang, X.S.; Huang, H.
    Substrate diversity of L-threonic acid dehydrogenase homologs (2020), Biochemistry (Moscow), 85, 463-471.
    View publication on PubMed
Search for more literature for 1.1.1.411

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.62
-
 D-gluconate pH 8.0, 25°C Agrobacterium tumefaciens
1
-
 L-threonate pH 8.0, 25°C Agrobacterium tumefaciens
1.19
-
 L-threonate pH 8.0, 25°C Agrobacterium tumefaciens
1.98
-
 L-Idonate pH 8.0, 25°C Agrobacterium tumefaciens
3.6
-
 L-Idonate pH 8.0, 25°C Agrobacterium tumefaciens
4.45
-
 D-xylonate pH 8.0, 25°C Agrobacterium tumefaciens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-threonate + NAD+ Cupriavidus necator
-
 3-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NAD+ Cupriavidus necator ATCC 17699
-
 3-dehydro-L-erythronate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Agrobacterium tumefaciens B9JKN9
-
-
Agrobacterium tumefaciens B9J8U1
-
-
Agrobacterium tumefaciens ATCC BAA-868 B9JKN9
-
-
Agrobacterium tumefaciens ATCC BAA-868 B9J8U1
-
-
Chromohalobacter israelensis Q1QSN6
-
-
Chromohalobacter israelensis ATCC BAA-138 Q1QSN6
-
-
Cupriavidus necator Q0KBC7
-
-
Cupriavidus necator ATCC 17699 Q0KBC7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Agrobacterium tumefaciens
-
 Chromohalobacter israelensis
-
 Cupriavidus necator

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-gluconate + NAD+
-
 Agrobacterium tumefaciens ?
-
 ?
D-gluconate + NAD+
-
 Agrobacterium tumefaciens ATCC BAA-868 ?
-
 ?
D-xylonate + NAD+
-
 Agrobacterium tumefaciens ? + NADH + H+
-
 ?
D-xylonate + NAD+
-
 Agrobacterium tumefaciens ATCC BAA-868 ? + NADH + H+
-
 ?
L-idonate + NAD+
-
 Agrobacterium tumefaciens L-sorbosonic acid + NADH + H+
-
 ?
L-idonate + NAD+
-
 Agrobacterium tumefaciens ATCC BAA-868 L-sorbosonic acid + NADH + H+
-
 ?
L-threonate + NAD+
-
 Cupriavidus necator 2-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NAD+ specifically oxidizes L-threonic acid Chromohalobacter israelensis 2-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NAD+
-
 Agrobacterium tumefaciens 2-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NAD+
-
 Cupriavidus necator ATCC 17699 2-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NAD+ specifically oxidizes L-threonic acid Chromohalobacter israelensis ATCC BAA-138 2-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NAD+
-
 Agrobacterium tumefaciens ATCC BAA-868 2-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NAD+
-
 Cupriavidus necator 3-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NAD+
-
 Cupriavidus necator ATCC 17699 3-dehydro-L-erythronate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
L-threonic acid dehydrogenase
-
 Cupriavidus necator
L-threonic acid dehydrogenase
-
 Chromohalobacter israelensis
L-threonic acid dehydrogenase
-
 Agrobacterium tumefaciens
ThrDH
-
 Cupriavidus necator
ThrDH
-
 Chromohalobacter israelensis
ThrDH
-
 Agrobacterium tumefaciens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2
-
 L-threonate pH 8.0, 25°C Agrobacterium tumefaciens
15.2
-
 D-xylonate pH 8.0, 25°C Agrobacterium tumefaciens
16.4
-
 L-Idonate pH 8.0, 25°C Agrobacterium tumefaciens
20
-
 L-threonate pH 8.0, 25°C Agrobacterium tumefaciens
21.1
-
 L-Idonate pH 8.0, 25°C Agrobacterium tumefaciens
22.4
-
 D-gluconate pH 8.0, 25°C Agrobacterium tumefaciens

Cofactor

Cofactor Comment Organism Structure
NAD+ the enzyme is composed of two NAD-binding domains Cupriavidus necator
NAD+
-
 Chromohalobacter israelensis
NAD+
-
 Agrobacterium tumefaciens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.4
-
 D-xylonate pH 8.0, 25°C Agrobacterium tumefaciens
4.1
-
 L-threonate pH 8.0, 25°C Agrobacterium tumefaciens
5.8
-
 L-Idonate pH 8.0, 25°C Agrobacterium tumefaciens
8.3
-
 L-Idonate pH 8.0, 25°C Agrobacterium tumefaciens
16.8
-
 L-threonate pH 8.0, 25°C Agrobacterium tumefaciens
36
-
 D-gluconate pH 8.0, 25°C Agrobacterium tumefaciens