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Literature summary for 1.1.1.410 extracted from

  • Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
    Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars (2016), Proc. Natl. Acad. Sci. USA, 113, E4161-E4169.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.59
-
 D-erythronate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator
2.4
-
 D-erythronate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator

Organism

Organism UniProt Comment Textmining
Cupriavidus necator Q0KBD2
-
-
Cupriavidus necator DSM 428 Q0KBD2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-erythronate + NAD+
-
 Cupriavidus necator 2-dehydro-D-erythronate + NADH + H+
-
 ?
D-erythronate + NAD+
-
 Cupriavidus necator DSM 428 2-dehydro-D-erythronate + NADH + H+
-
 ?
D-erythronate + NADP+
-
 Cupriavidus necator 2-dehydro-D-erythronate + NADPH + H+
-
 ?
D-erythronate + NADP+
-
 Cupriavidus necator DSM 428 2-dehydro-D-erythronate + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
D-erythronate 2-dehydrogenase
-
 Cupriavidus necator
denD
-
 Cupriavidus necator

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3
-
 D-erythronate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator
19
-
 D-erythronate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator

Cofactor

Cofactor Comment Organism Structure
NAD+ NAD+ is preferred over NADP+ Cupriavidus necator
NADP+ NAD+ is preferred over NADP+ Cupriavidus necator

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.2
-
 D-erythronate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator
33
-
 D-erythronate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator