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Literature summary for 1.1.1.41 extracted from

  • Hagras, A.; Toraih, E.; Fawzy, M.
    Mobile phones electromagnetic radiation and NAD (2016), Biochim. Open, 3, 19-25.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics enzyme NAD+-dependent isocitrate dehydrogenase cann act as a mitochondrial marker in asthenozoospermia Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NAD+ Homo sapiens
-
2-oxoglutarate + CO2 + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spermatozoon
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+
-
Homo sapiens 2-oxoglutarate + CO2 + NADH + H+
-
?

Subunits

Subunits Comment Organism
heterotetramer (alpha)2betagamma Homo sapiens

Synonyms

Synonyms Comment Organism
NAD+-dependent isocitrate dehydrogenase
-
Homo sapiens
NAD+-IDH
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

General Information

General Information Comment Organism
malfunction IDH activity is increased in patients with prolonged cell phone daily use over 4 h/day. Its level correlates negatively with either the motility ratio percentages or the progressive motility percentages in the study groups. NAD+-IDH in human seminal plasma can be one of seminal plasma biomarkers reflecting the mitochondrial function of spermatozoa. Alteration of its level reflect the defective motility of sperms among some cases of cellular phone users Homo sapiens
metabolism NAD-IDH is a key enzyme in the tricarboxylic acid cycle Homo sapiens