Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.41 extracted from

  • Igamberdiev, A.U.; Gardestrom, P.
    Regulation of NAD- and NADP-dependent isocitrate dehydrogenases by reduction levels of pyridine nucleotides in mitochondria and cytosol of pea leaves (2003), Biochim. Biophys. Acta, 1606, 117-125.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is not affected by NADP+, HCO3-, and 2-oxoglutarate Pisum sativum

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme is not affected by NADP+, HCO3-, and 2-oxoglutarate Pisum sativum
NADH competitive Pisum sativum
NADPH noncompetitive Pisum sativum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
isocitrate pH 7.5 Pisum sativum
0.2
-
NAD+ pH 7.5 Pisum sativum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Pisum sativum 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
Pisum sativum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NAD+ Pisum sativum pyridine nucleotide contents in mitochondria and cytosol, regulation, overview 2-oxoglutarate + CO2 + NADH + H+
-
ir

Organism

Organism UniProt Comment Textmining
Pisum sativum
-
cv. 294 040 Märgärt Kelvedon Wonder
-

Purification (Commentary)

Purification (Comment) Organism
partially by mitochondrion isolation in a Percoll gradient, and ammonium sulfate precipitation in the 60-80% fraction, DEAE cellulose chromatography, and desalting Pisum sativum

Source Tissue

Source Tissue Comment Organism Textmining
leaf green and etiolated Pisum sativum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.084
-
mitochondria from green leaves, forward reaction Pisum sativum
0.096
-
mitochondria from etiolated leaves, forward reaction Pisum sativum

Storage Stability

Storage Stability Organism
-80°C, partially purified enzyme, several months, stable Pisum sativum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+ pyridine nucleotide contents in mitochondria and cytosol, regulation, overview Pisum sativum 2-oxoglutarate + CO2 + NADH + H+
-
ir
threo-Ds-isocitrate + NAD+
-
Pisum sativum 2-oxoglutarate + CO2 + NADH
-
ir

Synonyms

Synonyms Comment Organism
NAD+-dependent ICDH
-
Pisum sativum
NAD-dependent isocitrate dehydrogenase
-
Pisum sativum
NAD-ICDH
-
Pisum sativum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Pisum sativum

Cofactor

Cofactor Comment Organism Structure
NAD+ specific for Pisum sativum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.18
-
NADH pH 7.5 Pisum sativum
0.26
-
NADPH pH 7.5 Pisum sativum