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Literature summary for 1.1.1.41 extracted from

  • Cohen, P.F.; Colman, R.F.
    Role of manganous ion in the kinetics of pig-heart NAD-specific isocitrate dehydrogenase (1974), Eur. J. Biochem., 47, 35-45.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ less effective than Mg2+ or Mn2+ Sus scrofa
Mg2+ required, active substrate is Mg-DL-isocitrate chelate Sus scrofa
Mn2+ requires divalent cations Sus scrofa
Zn2+ less effective than Mn2+ or Mg2+ Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NAD+ Sus scrofa
-
2-oxoglutarate + CO2 + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Sus scrofa
-

Storage Stability

Storage Stability Organism
-90°C, no loss of activity after 6 weeks Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+
-
Sus scrofa 2-oxoglutarate + CO2 + NADH + H+
-
?

pH Range

pH Minimum pH Maximum Comment Organism
6 8
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Sus scrofa