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Literature summary for 1.1.1.370 extracted from

  • Morinaga, T.; Ashida, H.; Yoshida, K.
    Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis (2010), Microbiology, 156, 1538-1546.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli as a C-terminally His6-tagged fusion protein Bacillus subtilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.019
-
NADH pH 7.5, 37°C Bacillus subtilis
0.15
-
NAD+ pH 7.5, 37°C Bacillus subtilis
2.85
-
2,4,6/3,5-pentahydroxycyclohexanone pH 7.5, 37°C Bacillus subtilis
2.85
-
scyllo-inosose pH 7.5, 37°C Bacillus subtilis
17.1
-
scyllo-Inositol pH 7.5, 37°C Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
scyllo-inositol + NAD+ Bacillus subtilis the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
r
scyllo-inositol + NAD+ Bacillus subtilis 168 the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Bacillus subtilis P40332
-
-
Bacillus subtilis 168 P40332
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bacillus subtilis

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:scyllo-inositol-grown cell
-
Bacillus subtilis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
scyllo-inositol + NAD+ no activity with NADP+ Bacillus subtilis 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ 2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose r
scyllo-inositol + NAD+ the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA Bacillus subtilis 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
r
scyllo-inositol + NAD+ no activity with NADP+ Bacillus subtilis 168 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ 2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose r
scyllo-inositol + NAD+ the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA Bacillus subtilis 168 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
r
scyllo-inositol + NAD+
-
Bacillus subtilis scyllo-inosose + NADH + H+
-
r
scyllo-inositol + NAD+
-
Bacillus subtilis 168 scyllo-inosose + NADH + H+
-
r
scyllo-inosose + NADH + H+
-
Bacillus subtilis scyllo-inositol + NAD+
-
r
scyllo-inosose + NADH + H+
-
Bacillus subtilis 168 scyllo-inositol + NAD+
-
r

Synonyms

Synonyms Comment Organism
IolX
-
Bacillus subtilis
yisS formeryl, gene name Bacillus subtilis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bacillus subtilis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Bacillus subtilis

Cofactor

Cofactor Comment Organism Structure
additional information no activity with NADP+ Bacillus subtilis
NAD+
-
Bacillus subtilis
NAD+ no activity with NADP+ Bacillus subtilis
NADH
-
Bacillus subtilis

Expression

Organism Comment Expression
Bacillus subtilis induced during growth on scyllo-inositol up
Bacillus subtilis enzyme is prominently expressed when Bacillus subtilis is grown on medium containing scyllo-inositol up

General Information

General Information Comment Organism
malfunction inactivation of iolX impairs growth with scyllo-inositol as the carbon source Bacillus subtilis
physiological function the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA Bacillus subtilis