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Literature summary for 1.1.1.37 extracted from

  • Pradhan, A.; Mukherjee, P.; Tripathi, A.K.; Avery, M.A.; Walker, L.A.; Tekwani, B.L.
    Analysis of quaternary structure of a [LDH-like] malate dehydrogenase of Plasmodium falciparum with oligomeric mutants (2009), Mol. Cell. Biochem., 325, 141-148.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli M15 (pREP4) cells Plasmodium falciparum

Protein Variants

Protein Variants Comment Organism
R183a dimeric mutant with almost wild type activity Plasmodium falciparum
R214G dimeric mutant with almost wild type activity Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04954
-
oxaloacetate wild type enzyme Plasmodium falciparum
0.04955
-
3-acetylpyridine-adenine dinucleotide wild type enzyme Plasmodium falciparum
0.06186
-
oxaloacetate mutant enzyme R214G Plasmodium falciparum
0.07238
-
NADH wild type enzyme Plasmodium falciparum
0.08074
-
oxaloacetate mutant enzyme R183A Plasmodium falciparum
0.0962
-
3-acetylpyridine-adenine dinucleotide mutant enzyme R214G Plasmodium falciparum
0.1114
-
3-acetylpyridine-adenine dinucleotide mutant enzyme R183A Plasmodium falciparum
0.1197
-
NADH mutant enzyme R214G Plasmodium falciparum
0.1231
-
NADH mutant enzyme R183A Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36100
-
4 * 36100, calculated from amino acid sequence Plasmodium falciparum
160000
-
enzymatically active preparation of recombinant wild type MDH, calculated from amino acid sequence Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + 3-acetylpyridine-adenine dinucleotide Plasmodium falciparum can also use 3-acetylpyridine-adenine as cofactor oxaloacetate + reduced 3-acetylpyridine-adenine dinucleotide + H+
-
r
(S)-malate + NAD+ Plasmodium falciparum highly specific for oxaloacetate and malate oxaloacetate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + 3-acetylpyridine-adenine dinucleotide can also use 3-acetylpyridine-adenine as cofactor Plasmodium falciparum oxaloacetate + reduced 3-acetylpyridine-adenine dinucleotide + H+
-
r
(S)-malate + NAD+ highly specific for oxaloacetate and malate Plasmodium falciparum oxaloacetate + NADH + H+
-
r

Subunits

Subunits Comment Organism
homotetramer 4 * 36100, calculated from amino acid sequence Plasmodium falciparum

Synonyms

Synonyms Comment Organism
L-malate dehydrogenase
-
Plasmodium falciparum
MDH
-
Plasmodium falciparum
[LDH-like] MDH
-
Plasmodium falciparum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
7280
-
3-acetylpyridine-adenine dinucleotide mutant enzyme R183A Plasmodium falciparum
7300
-
3-acetylpyridine-adenine dinucleotide wild type enzyme Plasmodium falciparum
7500
-
oxaloacetate mutant enzyme R214G Plasmodium falciparum
7880
-
NADH wild type enzyme Plasmodium falciparum
8320
-
oxaloacetate mutant enzyme R183A Plasmodium falciparum
8440
-
NADH mutant enzyme R214G Plasmodium falciparum
8570
-
oxaloacetate wild type enzyme Plasmodium falciparum
8860
-
NADH mutant enzyme R183A Plasmodium falciparum
10050
-
3-acetylpyridine-adenine dinucleotide mutant enzyme R214G Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
3-acetylpyridine-adenine dinucleotide
-
Plasmodium falciparum
NADH
-
Plasmodium falciparum