Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli M15 (pREP4) cells | Plasmodium falciparum |
Protein Variants | Comment | Organism |
---|---|---|
R183a | dimeric mutant with almost wild type activity | Plasmodium falciparum |
R214G | dimeric mutant with almost wild type activity | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04954 | - |
oxaloacetate | wild type enzyme | Plasmodium falciparum | |
0.04955 | - |
3-acetylpyridine-adenine dinucleotide | wild type enzyme | Plasmodium falciparum | |
0.06186 | - |
oxaloacetate | mutant enzyme R214G | Plasmodium falciparum | |
0.07238 | - |
NADH | wild type enzyme | Plasmodium falciparum | |
0.08074 | - |
oxaloacetate | mutant enzyme R183A | Plasmodium falciparum | |
0.0962 | - |
3-acetylpyridine-adenine dinucleotide | mutant enzyme R214G | Plasmodium falciparum | |
0.1114 | - |
3-acetylpyridine-adenine dinucleotide | mutant enzyme R183A | Plasmodium falciparum | |
0.1197 | - |
NADH | mutant enzyme R214G | Plasmodium falciparum | |
0.1231 | - |
NADH | mutant enzyme R183A | Plasmodium falciparum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36100 | - |
4 * 36100, calculated from amino acid sequence | Plasmodium falciparum |
160000 | - |
enzymatically active preparation of recombinant wild type MDH, calculated from amino acid sequence | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + 3-acetylpyridine-adenine dinucleotide | Plasmodium falciparum | can also use 3-acetylpyridine-adenine as cofactor | oxaloacetate + reduced 3-acetylpyridine-adenine dinucleotide + H+ | - |
r | |
(S)-malate + NAD+ | Plasmodium falciparum | highly specific for oxaloacetate and malate | oxaloacetate + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + 3-acetylpyridine-adenine dinucleotide | can also use 3-acetylpyridine-adenine as cofactor | Plasmodium falciparum | oxaloacetate + reduced 3-acetylpyridine-adenine dinucleotide + H+ | - |
r | |
(S)-malate + NAD+ | highly specific for oxaloacetate and malate | Plasmodium falciparum | oxaloacetate + NADH + H+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
homotetramer | 4 * 36100, calculated from amino acid sequence | Plasmodium falciparum |
Synonyms | Comment | Organism |
---|---|---|
L-malate dehydrogenase | - |
Plasmodium falciparum |
MDH | - |
Plasmodium falciparum |
[LDH-like] MDH | - |
Plasmodium falciparum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
7280 | - |
3-acetylpyridine-adenine dinucleotide | mutant enzyme R183A | Plasmodium falciparum | |
7300 | - |
3-acetylpyridine-adenine dinucleotide | wild type enzyme | Plasmodium falciparum | |
7500 | - |
oxaloacetate | mutant enzyme R214G | Plasmodium falciparum | |
7880 | - |
NADH | wild type enzyme | Plasmodium falciparum | |
8320 | - |
oxaloacetate | mutant enzyme R183A | Plasmodium falciparum | |
8440 | - |
NADH | mutant enzyme R214G | Plasmodium falciparum | |
8570 | - |
oxaloacetate | wild type enzyme | Plasmodium falciparum | |
8860 | - |
NADH | mutant enzyme R183A | Plasmodium falciparum | |
10050 | - |
3-acetylpyridine-adenine dinucleotide | mutant enzyme R214G | Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
3-acetylpyridine-adenine dinucleotide | - |
Plasmodium falciparum | |
NADH | - |
Plasmodium falciparum |