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Literature summary for 1.1.1.37 extracted from

  • Lee, S.M.; Kim, J.H.; Cho, E.J.; Youn, H.D.
    A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress (2009), Cell Death Differ., 16, 738-748.
    View publication on PubMed
Search for more literature for 1.1.1.37

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
H187Y catalytically inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleoplasm
-
 Homo sapiens 5654
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens MDH1 stabilizes and transactivates p53 protein by binding to p53-responsive elements in the promotor of downstream genes, MDH1 directly regulates p53-dependent apoptosis upon glucose deprivation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
 Homo sapiens oxaloacetate + NADH + H+
-
 r
additional information MDH1 stabilizes and transactivates p53 protein by binding to p53-responsive elements in the promotor of downstream genes, MDH1 directly regulates p53-dependent apoptosis upon glucose deprivation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
malate dehydrogenase 1
-
 Homo sapiens
Mdh1
-
 Homo sapiens
NAD+-dependent malate dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens