Any feedback?
Literature summary for 1.1.1.37 extracted from
- Purification and properties of Drosophila malate dehydrogenase (1970), Biochim. Biophys. Acta, 198, 165-175.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| oxaloacetate | - |
Drosophila virilis |  |
| oxaloacetate | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
oxaloacetate | cytoplasmic enzyme | Drosophila virilis | |
| 0.047 | - |
oxaloacetate | mitochondrial enzyme | Drosophila virilis | |
| 8 | - |
L-malate | cytoplasmic isoenzyme | Drosophila virilis | |
| 20 | - |
L-malate | mitochondrial isoenzyme | Drosophila virilis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Sus scrofa | 5737 | - |
| cytoplasm | - |
Bos taurus | 5737 | - |
| cytoplasm | - |
Gallus sp. | 5737 | - |
| cytoplasm | - |
Drosophila virilis | 5737 | - |
| cytoplasm | - |
Equus sp. | 5737 | - |
| cytoplasm | - |
Thunnus albacares | 5737 | - |
| mitochondrion | - |
Drosophila melanogaster | 5739 | - |
| mitochondrion | - |
Sus scrofa | 5739 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
| mitochondrion | - |
Gallus sp. | 5739 | - |
| mitochondrion | - |
Drosophila virilis | 5739 | - |
| mitochondrion | - |
Equus sp. | 5739 | - |
| mitochondrion | - |
Thunnus albacares | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 67000 | - |
- |
Sus scrofa |
| 67000 | - |
- |
Gallus sp. |
| 67000 | - |
- |
Thunnus albacares |
| 68000 | - |
- |
Sus scrofa |
| 68000 | - |
both isoenzymes, gel filtration | Drosophila melanogaster |
| 68000 | - |
both isoenzymes, gel filtration | Drosophila virilis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| malate + NAD+ | Drosophila melanogaster | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Sus scrofa | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Bos taurus | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Locusta migratoria | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Gallus sp. | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Drosophila virilis | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Equus sp. | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Thunnus albacares | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Drosophila melanogaster Oregon K | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Drosophila virilis Texmelucan | - |
oxaloacetate + NADH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
ox | - |
| Drosophila melanogaster | - |
Oregon K | - |
| Drosophila melanogaster Oregon K | - |
Oregon K | - |
| Drosophila virilis | - |
Texmelucan | - |
| Drosophila virilis Texmelucan | - |
Texmelucan | - |
| Equus sp. | - |
horse | - |
| Gallus sp. | - |
chicken | - |
| Locusta migratoria | - |
- |
- |
| Sus scrofa | - |
pig | - |
| Thunnus albacares | - |
tuna | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Drosophila melanogaster |
- |
Locusta migratoria |
- |
Drosophila virilis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Sus scrofa | - |
| heart | - |
Bos taurus | - |
| heart | - |
Gallus sp. | - |
| heart | - |
Equus sp. | - |
| heart | - |
Thunnus albacares | - |
| kidney | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1670 | - |
- |
Drosophila virilis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-malate + NAD+ | - |
Drosophila melanogaster | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Sus scrofa | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Bos taurus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Locusta migratoria | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Gallus sp. | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Drosophila virilis | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Equus sp. | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Thunnus albacares | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Drosophila melanogaster Oregon K | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Drosophila virilis Texmelucan | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Drosophila melanogaster | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Sus scrofa | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Bos taurus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Locusta migratoria | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Gallus sp. | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Drosophila virilis | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Equus sp. | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Thunnus albacares | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Drosophila melanogaster Oregon K | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Drosophila virilis Texmelucan | oxaloacetate + NADH + H+ | - |
r | |
| oxaloacetate + NADH | - |
Drosophila melanogaster | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Sus scrofa | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Bos taurus | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Locusta migratoria | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Gallus sp. | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Drosophila virilis | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Equus sp. | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Thunnus albacares | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Drosophila melanogaster Oregon K | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Drosophila virilis Texmelucan | L-malate + NAD+ | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
oxaloacetate reduction | Drosophila melanogaster |
| 8.5 | - |
oxaloacetate reduction | Drosophila virilis |
| 9 | - |
malate oxidation, cytoplasmic isoenzymes | Drosophila melanogaster |
| 9 | - |
malate oxidation, cytoplasmic isoenzymes | Drosophila virilis |
| 9.5 | - |
mitochondrial isoenzyme | Drosophila melanogaster |
| 9.5 | - |
mitochondrial isoenzyme | Drosophila virilis |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
