Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.352 extracted from

  • Sakuno, E.; Yabe, K.; Hamasaki, T.; Nakajima, H.
    A new inhibitor of 5-hydroxyaverantin dehydrogenase, an enzyme involved in aflatoxin biosynthesis, from Trichoderma hamatum (2000), J. Nat. Prod., 63, 1677-1678.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4,6-dihydroxy-5-methoxy-6a-methylcyclohexa[de]indano-[7,6-e]cyclopenta[c]2H-pyran-1,9-dione TAEMC161, specific inhibitor Aspergillus parasiticus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Aspergillus parasiticus 5829
-

Organism

Organism UniProt Comment Textmining
Aspergillus parasiticus
-
-
-
Aspergillus parasiticus NIAH-26
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, butyl-Toyopearl 650 M column chromatography Aspergillus parasiticus

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Aspergillus parasiticus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1'S,5'S)-hydroxyaverantin + NAD+
-
Aspergillus parasiticus 5'-oxoaverantin + NADH + H+
-
?
(1'S,5'S)-hydroxyaverantin + NAD+
-
Aspergillus parasiticus NIAH-26 5'-oxoaverantin + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
HAVN dehydrogenase
-
Aspergillus parasiticus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Aspergillus parasiticus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.25
-
in 50 mM Tris-HCl buffer (pH 8.5), at 33°C Aspergillus parasiticus 4,6-dihydroxy-5-methoxy-6a-methylcyclohexa[de]indano-[7,6-e]cyclopenta[c]2H-pyran-1,9-dione