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Literature summary for 1.1.1.352 extracted from

  • Sakuno, E.; Yabe, K.; Nakajima, H.
    Involvement of two cytosolic enzymes and a novel intermediate, 5-oxoaverantin, in the pathway from 5-hydroxyaverantin to averufin in aflatoxin biosynthesis (2003), Appl. Environ. Microbiol., 69, 6418-6426.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.083
-
5'-hydroxyaverantin in 60 mM potassium phosphate buffer (pH 7.5), at 30°C Aspergillus parasiticus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Aspergillus parasiticus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
2 * 28000, SDS-PAGE Aspergillus parasiticus
29600
-
2 * 29600, calculated from amino acid sequence Aspergillus parasiticus
60000
-
gel filtration Aspergillus parasiticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-hydroxyaverantin + NAD+ Aspergillus parasiticus
-
5'-oxoaverantin + NADH + H+
-
?
5'-hydroxyaverantin + NAD+ Aspergillus parasiticus NIAH-26
-
5'-oxoaverantin + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus parasiticus
-
-
-
Aspergillus parasiticus NIAH-26
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, DE 52 column chromatography, butyl Toyopearl column chromatography, hydroxyapatite column chromatography, Mono Q column chromatography, Resource Q column chromatography, and Superdex 200 gel filtration Aspergillus parasiticus

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Aspergillus parasiticus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000032
-
crude enzyme, in 60 mM potassium phosphate buffer (pH 7.5), at 30°C Aspergillus parasiticus
0.0222
-
after 694fold purification, in 60 mM potassium phosphate buffer (pH 7.5), at 30°C Aspergillus parasiticus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-hydroxyaverantin + NAD+
-
Aspergillus parasiticus 5'-oxoaverantin + NADH + H+
-
?
5'-hydroxyaverantin + NAD+
-
Aspergillus parasiticus NIAH-26 5'-oxoaverantin + NADH + H+
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 28000, SDS-PAGE Aspergillus parasiticus
homodimer 2 * 29600, calculated from amino acid sequence Aspergillus parasiticus

Synonyms

Synonyms Comment Organism
AdhA
-
Aspergillus parasiticus
HAVN dehydrogenase
-
Aspergillus parasiticus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30 35
-
Aspergillus parasiticus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
20 40
-
Aspergillus parasiticus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8.5
-
Aspergillus parasiticus

Cofactor

Cofactor Comment Organism Structure
NAD+ required for activity Aspergillus parasiticus