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Literature summary for 1.1.1.30 extracted from

  • Guo, K.; Lukacik, P.; Papagrigoriou, E.; Meier, M.; Lee, W.H.; Adamski, J.; Oppermann, U.
    Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase (2006), J. Biol. Chem., 281, 10291-10297.
    View publication on PubMed
Search for more literature for 1.1.1.30

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion method at 20°C, structure determined at a resolution of 1.8 A in complex with NAD(H) Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0598
-
 NAD+ 25°C, pH 9.0 Homo sapiens
9.1
-
 (R)-3-hydroxybutanoate 30°C, pH 9.0 Homo sapiens
10.5
-
 (R)-3-hydroxybutanoate 25°C, pH 9.0 Homo sapiens
12.6
-
 (R)-3-hydroxybutanoate 25°C, pH 7.5 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+
-
 Homo sapiens acetoacetate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
beta-hydroxybutyrate dehydrogenase
-
 Homo sapiens
DHRS6
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens