Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.30 extracted from

  • Kovar, J.; Matyskova, I.; Matyska, L.
    Kinetics of D-3-hydroxybutyrate dehydrogenase from Paracoccus denitrificans (1986), Biochim. Biophys. Acta, 871, 302-309.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine
-
Paracoccus denitrificans

Inhibitors

Inhibitors Comment Organism Structure
(DL)-2-hydroxybutyrate 5 mM, pH 8.5, 25°, 69% inhibition Paracoccus denitrificans
(DL)-lactate 5 mM, pH 8.5, 25°C, 65% inhibition Paracoccus denitrificans
ADP-ribose competitive inhibition vs. coenzyme, noncompetitive vs. substrate Paracoccus denitrificans
Butyrate 5 mM, pH 8.5, 25°C, 22% inhibition Paracoccus denitrificans
D-lactate 5 mM, pH 8.5, 25°, 85% inhibition, uncompetitive vs. coenzyme, competitive vs. substrate Paracoccus denitrificans
L-3-hydroxybutyrate 5 mM, pH 8.5, 25°C, 23% inhibition; 5 mM, pH 8.5, 25°C, 32% inhibition Paracoccus denitrificans
propionate 5 mM, pH 8.5, 25°C, 9% inhibition Paracoccus denitrificans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+ Paracoccus denitrificans
-
acetoacetate + NADH
-
r

Organism

Organism UniProt Comment Textmining
Paracoccus denitrificans
-
enzyme shows hysteresis, lag phase in progress curve
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+
-
Paracoccus denitrificans acetoacetate + NADH
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
reduction of acetoacetate Paracoccus denitrificans
8.5
-
oxidation of beta-hydroxybutyrate Paracoccus denitrificans

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Paracoccus denitrificans