Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphatidylcholine | - |
Homo sapiens | |
phosphatidylcholine | - |
Bos taurus |
Cloned (Comment) | Organism |
---|---|
mature form, expressed in Spodoptera frugiperda, SF9 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C242S | PCR derived cDNA clone | Homo sapiens |
M92V | PCR derived cDNA clone | Homo sapiens |
S24T | PCR derived cDNA clone | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.53 | - |
NAD+ | enzyme expressed in SF9 cells | Homo sapiens | |
0.59 | - |
(R)-3-hydroxybutanoate | submitochondrial vesicles | Bos taurus | |
0.71 | - |
(R)-3-hydroxybutanoate | enzyme expressed in SF9 cells | Homo sapiens | |
0.8 | - |
NAD+ | enzyme expressed in SF9 cells, C242S mutant | Homo sapiens | |
0.95 | - |
NAD+ | submitochondrial vesicles | Bos taurus | |
10 | - |
(R)-3-hydroxybutanoate | enzyme expressed in SF9 cells, C242S mutant, C242 important for substrate binding | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
cytoplasm | - |
Bos taurus | 5737 | - |
mitochondrion | located on the matrix face of the inner membrane | Homo sapiens | 5739 | - |
mitochondrion | located on the matrix face of the inner membrane | Bos taurus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-3-hydroxybutanoate + NAD+ | Homo sapiens | - |
acetoacetate + NADH | - |
r | |
(R)-3-hydroxybutanoate + NAD+ | Bos taurus | - |
acetoacetate + NADH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
heart | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.17 | - |
solubilized apo-3-hydroxybutyrate dehydrogenase, reconstituted with phosphatidylcholine/phosphatidylethanolamine/diphosphatidylglycerol, 5/4/1 | Bos taurus |
0.22 | - |
apo-3-hydroxybutyrate dehydrogenase, reconstituted with phosphatidylcholine/phosphatidylethanolamine/diphosphatidylglycerol, 5/4/1 | Homo sapiens |
0.5 | - |
enzyme expressed in SF9 cells, S24T mutatant | Homo sapiens |
0.52 | - |
submitochondrial vesicles, membrane bound enzyme | Bos taurus |
0.6 | - |
enzyme expressed in SF9 cells, M92V mutatant | Homo sapiens |
0.63 | - |
enzyme expressed in SF9 cells, membrane bound | Homo sapiens |
0.8 | - |
enzyme expressed in SF9 cells, C242S mutatant | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-3-hydroxybutanoate + NAD+ | - |
Homo sapiens | acetoacetate + NADH | - |
r | |
(R)-3-hydroxybutanoate + NAD+ | - |
Bos taurus | acetoacetate + NADH | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Bos taurus |