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Literature summary for 1.1.1.283 extracted from
- A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase (2007), FEMS Yeast Res., 7, 84-92.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | creation of a knockout mutant that forms large, invasive filaments | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | important role in the suppression of filamentation in response to isoamyl alcohol | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
wild type strains IWD72 and BY4741 and enzyme knockout mutants, knockout mutant forms large, invasive filaments, activity increases at 5-6 h of cultivation in the presence of 0.5% isoamyl alcohol and then quickly declines to become undetectable after 8 h | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methylglyoxal + NADPH + H+ | - |
Saccharomyces cerevisiae | lactaldehyde + NADP+ | - |
? | |
| additional information | important role in the suppression of filamentation in response to isoamyl alcohol | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | enzyme displays also isovaleraldehyde reductase activity (EC 1.1.1.265) | Saccharomyces cerevisiae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| D-lactaldehyde dehydrogenase | for the reverse reaction | Saccharomyces cerevisiae |
| GRE2 gene product | - |
Saccharomyces cerevisiae |
| Gre2p | - |
Saccharomyces cerevisiae |
| methylglyoxal reductase | - |
Saccharomyces cerevisiae |
| methylglyoxal reductase (NADPH dependent) | - |
Saccharomyces cerevisiae |
| More | enzyme displays also isovaleraldehyde reductase activity (EC 1.1.1.265) | Saccharomyces cerevisiae |
| YOL151w gene product | - |
Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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