Literature summary for 1.1.1.283 extracted from

Hauser, M.; Horn, P.; Tournu, H.; Hauser, N.C.; Hoheisel, J.D.; Brown, A.J.; Dickinson, J.R.
A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase (2007), FEMS Yeast Res., 7, 84-92.

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Protein Variants

Protein Variants	Comment	Organism
additional information	creation of a knockout mutant that forms large, invasive filaments	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Saccharomyces cerevisiae	important role in the suppression of filamentation in response to isoamyl alcohol	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	wild type strains IWD72 and BY4741 and enzyme knockout mutants, knockout mutant forms large, invasive filaments, activity increases at 5-6 h of cultivation in the presence of 0.5% isoamyl alcohol and then quickly declines to become undetectable after 8 h	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
methylglyoxal + NADPH + H+	-	Saccharomyces cerevisiae	lactaldehyde + NADP+	-	?
additional information	important role in the suppression of filamentation in response to isoamyl alcohol	Saccharomyces cerevisiae	?	-	?
additional information	enzyme displays also isovaleraldehyde reductase activity (EC 1.1.1.265)	Saccharomyces cerevisiae	?	-	?

Synonyms

Synonyms	Comment	Organism
D-lactaldehyde dehydrogenase	for the reverse reaction	Saccharomyces cerevisiae
GRE2 gene product	-	Saccharomyces cerevisiae
Gre2p	-	Saccharomyces cerevisiae
methylglyoxal reductase	-	Saccharomyces cerevisiae
methylglyoxal reductase (NADPH dependent)	-	Saccharomyces cerevisiae
More	enzyme displays also isovaleraldehyde reductase activity (EC 1.1.1.265)	Saccharomyces cerevisiae
YOL151w gene product	-	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)