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Literature summary for 1.1.1.266 extracted from
- A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose (1999), J. Biol. Chem., 274, 16933-16939.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Aggregatibacter actinomycetemcomitans |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.029 | - |
NADPH | sequential reaction mechanism | Aggregatibacter actinomycetemcomitans |  |
| 0.097 | - |
dTDP-4-keto-6-deoxy-D-glucose | sequential reaction mechnism | Aggregatibacter actinomycetemcomitans | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dTDP-D-fucose + NADP+ | Aggregatibacter actinomycetemcomitans | - |
dTDP-4-dehydro-6-deoxy-D-glucose + NADPH | - |
r | |
| dTDP-D-fucose + NADP+ | Aggregatibacter actinomycetemcomitans Y4 | - |
dTDP-4-dehydro-6-deoxy-D-glucose + NADPH | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aggregatibacter actinomycetemcomitans | - |
serotype b | - |
| Aggregatibacter actinomycetemcomitans Y4 | - |
serotype b | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity, recombinant enzyme | Aggregatibacter actinomycetemcomitans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dTDP-D-fucose + NADP+ | - |
Aggregatibacter actinomycetemcomitans | dTDP-4-dehydro-6-deoxy-D-glucose + NADPH | - |
r | |
| dTDP-D-fucose + NADP+ | - |
Aggregatibacter actinomycetemcomitans Y4 | dTDP-4-dehydro-6-deoxy-D-glucose + NADPH | - |
r | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 43.5 | - |
dTDP-4-keto-6-deoxy-D-glucose | - |
Aggregatibacter actinomycetemcomitans | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Aggregatibacter actinomycetemcomitans | |
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Release 2023.1 (January 2023)
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