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Literature summary for 1.1.1.219 extracted from

  • Petit, P.; Granier, T.; dEstaintot, B.L.; Manigand, C.; Bathany, K.; Schmitter, J.M.; Lauvergeat, V.; Hamdi, S.; Gallois, B.
    Crystal structure of grape dihydroflavonol 4-reductase, a key enzyme in flavonoid biosynthesis (2007), J. Mol. Biol., 368, 1345-1357.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Vitis vinifera

Crystallization (Commentary)

Crystallization (Comment) Organism
purified recombinant enzyme in complex with NADPH and dihydroquercetin, X-ray diffraction structure determination and analysis at 1.8 A resolution Vitis vinifera

Protein Variants

Protein Variants Comment Organism
N133D site-directed mutagenesis, Vitis vinifera

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dihydrokaempferol + NADPH Vitis vinifera
-
cis-3,4-leucopelargonidin + NADP+
-
r
dihydromyricetin + NADPH Vitis vinifera
-
leucodelphinidin + NADP+
-
r
dihydroquercetin + NADPH Vitis vinifera
-
leucocyanidin + NADP+
-
r
additional information Vitis vinifera the key enzyme in flavonoid biosynthesis catalyzes a late step in the biosynthesis of anthocyanins and condensed tannins, two flavonoid classes of importance to plant survival and human nutrition, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Vitis vinifera
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinanet enzyme from Escherichia coli Vitis vinifera

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrokaempferol + NADPH
-
Vitis vinifera cis-3,4-leucopelargonidin + NADP+
-
r
dihydromyricetin + NADPH
-
Vitis vinifera leucodelphinidin + NADP+
-
r
dihydroquercetin + NADPH
-
Vitis vinifera leucocyanidin + NADP+
-
r
additional information the key enzyme in flavonoid biosynthesis catalyzes a late step in the biosynthesis of anthocyanins and condensed tannins, two flavonoid classes of importance to plant survival and human nutrition, overview Vitis vinifera ?
-
?
additional information the specific residue at position 133, Asn or Asp, is involved in controling of the substrate recognition and recognition of the B-ring hydroxylation pattern of dihydroflavonols, structure-function relationship, overview Vitis vinifera ?
-
?

Subunits

Subunits Comment Organism
More 3D structure of the ternary complex, overview Vitis vinifera

Synonyms

Synonyms Comment Organism
DFR
-
Vitis vinifera
dihydroflavonol 4-reductase
-
Vitis vinifera

Cofactor

Cofactor Comment Organism Structure
NADP+ binding site structure, overview Vitis vinifera
NADPH
-
Vitis vinifera