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Literature summary for 1.1.1.218 extracted from

  • Todaka, T.; Ishida, T.; Kita, H.; Narimatsu, S.; Yamano, S.
    Bioactivation of morphine in human liver: isolation and identification of morphinone, a toxic metabolite (2005), Biol. Pharm. Bull., 28, 1275-1280.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5alpha-dihydrotestosterone 0.1 mM, complete inhibition Homo sapiens
5beta-dihydrotestosterone 0.1 mM, complete inhibition Homo sapiens
androsterone 0.1 mM, 76% inhibition Homo sapiens
Barbital 1mM, 68% inhibition Homo sapiens
chenodeoxycholic acid 0.1 mM, 24% inhibition Homo sapiens
cholic acid 0.1 mM, 10% inhibition Homo sapiens
epiandrosterone 0.1 mM, 77% inhibition Homo sapiens
estradiol 0.1 mM, complete inhibition Homo sapiens
indomethacin 1 mM, 84% inhibition Homo sapiens
Ketamine 1mM, 60% inhibition Homo sapiens
lithocholic acid 0.1 mM, 75% inhibition Homo sapiens
naloxone 1mM, 61% inhibition Homo sapiens
pyrazole 1 mM, 20% inhibition Homo sapiens
testosterone 0.1 mM, 100% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.5
-
morphine
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
morphine + NAD(P)+
-
Homo sapiens morphinone + NAD(P)H
-
ir

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.8
-
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD(P)+
-
Homo sapiens