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Literature summary for 1.1.1.218 extracted from

  • Yamano, S.; Takahashi, A.; Todaka, T.; Toki, S.
    In vivo and in vitro formation of morphinone from morphine in rat (1997), Xenobiotica, 27, 645-656.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5alpha-dihydrotestosterone
-
Rattus norvegicus
5beta-dihydrotestosterone
-
Rattus norvegicus
androsterone
-
Rattus norvegicus
estradiol
-
Rattus norvegicus
additional information no or weak inhibition by pyrazole, barbital Rattus norvegicus
quercetin
-
Rattus norvegicus
testosterone
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.9
-
morphine cosubstrate NAD+, in the male adult rats Rattus norvegicus
3.3
-
morphine cosubstrate NAD+, in the female adult rats Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome microsomal fraction Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Wistar
-
Rattus norvegicus Wistar
-
Wistar
-

Source Tissue

Source Tissue Comment Organism Textmining
bile
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
morphine + NADP+ + NAD+: enzyme activity ten times that with NADP+ Rattus norvegicus morphinone + NADPH + H+
-
?
morphine + NADP+ + NAD+: enzyme activity ten times that with NADP+ Rattus norvegicus Wistar morphinone + NADPH + H+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.3
-
in different buffers Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+ NADP+: only about one-tenth of activity with NAD+ Rattus norvegicus