Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Aedes aegypti |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.091 | - |
(2E,6E)-farnesol | pH 10.0, 30°C | Aedes aegypti | |
0.097 | - |
(2Z,6Z)-farnesol | pH 10.0, 30°C | Aedes aegypti | |
0.109 | - |
(Z)-nerol | pH 10.0, 30°C | Aedes aegypti | |
0.133 | - |
citronellol | pH 10.0, 30°C | Aedes aegypti | |
0.184 | - |
2-decanol | pH 10.0, 30°C | Aedes aegypti | |
0.195 | - |
Octanol | pH 10.0, 30°C | Aedes aegypti | |
0.208 | - |
(E)-geraniol | pH 10.0, 30°C | Aedes aegypti |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
29000 | - |
2 * 29000, calculated | Aedes aegypti |
60000 | - |
gel filtration | Aedes aegypti |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aedes aegypti | D2WKD9 | NADP+-dependent farnesol dehydrogenase 1 | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Aedes aegypti |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | and midgut, of adult female, highest levels of mRNA | Aedes aegypti | - |
corpora allata | no farnesol dehydrogenase activity in newly emerged mosquitoes but significant activity 24 h later. SDR-1 mRNA levels are very low in the inactive corpora allata of the newly emerged female, but increased over 30-fold 24 h later during the peak of juvenile hormone synthesis | Aedes aegypti | - |
fat body | and Malpighian tubules, considerable levles of mRNA | Aedes aegypti | - |
ganglion | abdominal and thoracic ganglia, high level of mRNA | Aedes aegypti | - |
malpighian tubule | and fat body, considerable levles of mRNA | Aedes aegypti | - |
midgut | and brain, of adult female, highest levels of mRNA | Aedes aegypti | - |
testis | of adult male, substantial level of mRNA | Aedes aegypti | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
9 | - |
substrate (2Z,6Z)-farnesol, pH 10.0, 30°C | Aedes aegypti |
9.7 | - |
substrate (2E,6E)-farnesol, pH 10.0, 30°C | Aedes aegypti |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesol + NADP+ | enzyme shows highest affinity for farnesol | Aedes aegypti | (2E,6E)-farnesal + NADPH + H+ | - |
ir | |
(2Z,6Z)-farnesol + NADP+ | enzyme shows highest affinity for farnesol | Aedes aegypti | (2Z,6Z)-farnesal + NADPH + H+ | - |
r | |
(E)-geraniol + NADP+ | - |
Aedes aegypti | (E)-geranial + NADPH + H+ | - |
? | |
(Z)-nerol + NADP+ | - |
Aedes aegypti | (Z)-neral + NADPH + H+ | - |
? | |
2-decanol + NADP+ | - |
Aedes aegypti | ? + NADPH + H+ | - |
? | |
citronellol + NADP+ | - |
Aedes aegypti | citronellal + NADPH + H+ | - |
? | |
additional information | no activity is detected for butanol, ethanol, or glycerol, or for farnesal or farnesoic acid | Aedes aegypti | ? | - |
? | |
octanol + NADP+ | - |
Aedes aegypti | octanal + NADPH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 29000, calculated | Aedes aegypti |
Synonyms | Comment | Organism |
---|---|---|
NADP+-dependent farnesol dehydrogenase 1 | - |
Aedes aegypti |
SDR-1 | - |
Aedes aegypti |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10 | 11 | - |
Aedes aegypti |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | absolutely required, NAD+ or FAD cannot substitute | Aedes aegypti |
Organism | Comment | Expression |
---|---|---|
Aedes aegypti | SDR-1 mRNA levels are very low in the inactive corpora allata of the newly emerged female, but increased over 30-fold 24 h later during the peak of juvenile hormone synthesis | additional information |