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Literature summary for 1.1.1.21 extracted from

  • Kim, N.H.; Kim, Y.S.; Lee, Y.M.; Jang, D.S.; Kim, J.S.
    Inhibition of aldose reductase and xylose-induced lens opacity by puerariafuran from the roots of Pueraria lobata (2010), Biol. Pharm. Bull., 33, 1605-1609.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
puerariafuran a 2-arylbenzofuran from Pueraria lobata, collected in Kyonggi-do, Seongnam, Kyungwon University, Korea. Xylose-induced opacity of lenses is significantly improved when treated with puerariafuran Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DL-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
DL-glycerol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
8-week-old Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH + H+
-
Rattus norvegicus DL-glycerol + NADP+
-
?

Synonyms

Synonyms Comment Organism
aldose reductase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0223
-
pH 7.0, 37°C Rattus norvegicus puerariafuran

General Information

General Information Comment Organism
physiological function high sugar levels found in diabetic cataract cause the opacification of lenses by osmotic changes induced via the aldose reductase-mediated polyol pathway Rattus norvegicus