Literature summary for 1.1.1.21 extracted from

Steuber, H.; Heine, A.; Podjarny, A.; Klebe, G.
Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features (2008), J. Mol. Biol., 379, 991-1016.

Search for more literature for 1.1.1.21

Protein Variants

Protein Variants	Comment	Organism
C303D	introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors	Homo sapiens
F121P	introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors	Homo sapiens
L300A	introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors	Homo sapiens
L301M	introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors	Homo sapiens
S302R	introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors	Homo sapiens
V47I	introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(2-[(4-bromo-2-fluorobenzyl)carbamoyl]-5-chlorophenoxy)acetic acid	thermodynamic binding data for isoform ALR2 and mutants	Homo sapiens
(3-[(5-chloro-1,3-benzothiazol-2-yl)methyl]-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid	thermodynamic binding data for isoform ALR2 and mutants	Homo sapiens
(5-chloro-2-[(3-nitrobenzyl)carbamoyl]phenoxy)acetic acid	thermodynamic binding data for isoform ALR2 and mutants	Homo sapiens
fidarestat	thermodynamic binding data for isoform ALR2 and mutants	Homo sapiens
sorbinil	thermodynamic binding data for isoform ALR2 and mutants	Homo sapiens
Tolrestat	thermodynamic binding data for isoform ALR2 and mutants	Homo sapiens
zopolrestat	thermodynamic binding data for isoform ALR2 and mutants	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15121	isoform ALR2	-

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Release 2023.1 (January 2023)