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Literature summary for 1.1.1.21 extracted from

  • Das-Evcimen, N.; Bozdag-Dundar, O.; Sarikaya, M.; Ertan, R.
    In vitro aldose reductase inhibitory activity of some flavonyl-2,4-thiazolidinediones (2008), J. Enzyme Inhib. Med. Chem., 23, 297-301.
    View publication on PubMed
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
(5E)-5-[4-(4-oxo-4H-chromen-2-yl)benzylidene]-1,3-thiazolidine-2,4-dione
-
 Rattus norvegicus
(5Z)-5-[(4-oxo-2-phenyl-4H-chromen-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
-
 Rattus norvegicus
5-[(4-oxo-2-phenyl-4H-chromen-6-yl)methyl]-1,3-thiazolidine-2,4-dione
-
 Rattus norvegicus
5-[3-(4-oxo-4H-chromen-2-yl)benzyl]-1,3-thiazolidine-2,4-dione
-
 Rattus norvegicus
5-[4-(4-oxo-4H-chromen-2-yl)benzyl]-1,3-thiazolidine-2,4-dione
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde + NAD(P)H
-
 Rattus norvegicus glycerol + NAD(P)+
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000432
-
 pH 6.2, 37°C Rattus norvegicus (5E)-5-[4-(4-oxo-4H-chromen-2-yl)benzylidene]-1,3-thiazolidine-2,4-dione
0.000432
-
 pH 6.2, 37°C Rattus norvegicus 5-[4-(4-oxo-4H-chromen-2-yl)benzyl]-1,3-thiazolidine-2,4-dione
0.000643
-
 pH 6.2, 37°C Rattus norvegicus 5-[(4-oxo-2-phenyl-4H-chromen-6-yl)methyl]-1,3-thiazolidine-2,4-dione
0.000683
-
 pH 6.2, 37°C Rattus norvegicus (5Z)-5-[(4-oxo-2-phenyl-4H-chromen-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
0.000687
-
 pH 6.2, 37°C Rattus norvegicus 5-[3-(4-oxo-4H-chromen-2-yl)benzyl]-1,3-thiazolidine-2,4-dione