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Literature summary for 1.1.1.21 extracted from

  • Bozdag-Duendar, O.; Evranos, B.; Das-Evcimen, N.; Sarikaya, M.; Ertan, R.
    Synthesis and aldose reductase inhibitory activity of some new chromonyl-2,4-thiazolidinediones (2008), Eur. J. Med. Chem., 43, 2412-2417.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2,4-dioxo-5-[(6,8-dimethyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl) acetic acid
-
Rattus norvegicus
(2,4-dioxo-5-[(6-isopropyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl) acetic acid
-
Rattus norvegicus
(2,4-dioxo-5-[(6-methyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl)acetic acid
-
Rattus norvegicus
(2,4-dioxo-5-[(6-nitro-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl)acetic acid
-
Rattus norvegicus
5-[(6-isopropyl-4-oxo-4H-chromen-3-yl)methylene]thiazolidine-2,4-dione
-
Rattus norvegicus
5-[(6-methyl-4-oxo-4H-chromen-3-yl)methylene]thiazolidine-2,4-dione
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH
-
Rattus norvegicus glycerol + NADP+
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000261
-
pH 6.2, 37°C Rattus norvegicus (2,4-dioxo-5-[(6-nitro-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl)acetic acid
0.000522
-
pH 6.2, 37°C Rattus norvegicus (2,4-dioxo-5-[(6-isopropyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl) acetic acid
0.000678
-
pH 6.2, 37°C Rattus norvegicus (2,4-dioxo-5-[(6,8-dimethyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl) acetic acid
0.000805
-
pH 6.2, 37°C Rattus norvegicus (2,4-dioxo-5-[(6-methyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl)acetic acid
0.000944
-
pH 6.2, 37°C Rattus norvegicus 5-[(6-methyl-4-oxo-4H-chromen-3-yl)methylene]thiazolidine-2,4-dione
0.000955
-
pH 6.2, 37°C Rattus norvegicus 5-[(6-isopropyl-4-oxo-4H-chromen-3-yl)methylene]thiazolidine-2,4-dione