Application | Comment | Organism |
---|---|---|
medicine | inhibition/antisense abolition of aldose reductase inhibits the tumor necrosis factor alpha-induced synthesis of prostaglandin E2 and the activity of cyclooxygenase. Inhibition of aldose reductase prevents tumor necrosis factor alpha-induced activation of protein kinase C and NF-kappaB which results in the abrogation of Cox-2 mRNA and protein expression | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | transient transfection of Caco-2 cells with aldose reductase antisense but not scrambled antisense oligonucleotides abolishes aldose reductase protein by more than 95%. Antisense abolition significantly prevents the tumor necrosis factor alpha-induced prostaglandin E2 production in Caco-2 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sorbinil | inhibition significantly prevents the tumor necrosis factor alpha-induced prostaglandin E2 production in Caco-2 cells | Homo sapiens | |
Tolrestat | inhibition significantly prevents the tumor necrosis factor alpha-induced prostaglandin E2 production in Caco-2 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |