Literature summary for 1.1.1.21 extracted from
Kayser, M.M.; Drolet, M.; Stewart, J.D.
Application of newly available bio-reducing agents to the synthesis of chiral hydroxy-beta-lactams: model for aldose reductase selectivity (2005), Tetrahedron Asymmetry, 16, 4004-4009.
No PubMed abstract available
Application
Application |
Comment |
Organism |
drug development |
homochiral 3-hydroxy-4-substituted beta-lactams serve as precursors to the corresponding alpah-hydroxy-beta-amino acids, the enzyme might be useful insynthesis of these key components of many biologically and therapeutically important compounds |
Saccharomyces cerevisiae |
synthesis |
homochiral 3-hydroxy-4-substituted beta-lactams serve as precursors to the corresponding alpah-hydroxy-beta-amino acids, the enzyme might be useful insynthesis of these key components of many biologically and therapeutically important compounds |
Saccharomyces cerevisiae |
Organism
Organism |
UniProt |
Comment |
Textmining |
Saccharomyces cerevisiae |
- |
- |
- |
Substrates and Products (Substrate)
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
(3R,4S/3S,4R)-3,4-(cis)acetate-beta-lactam + NADPH + H+ |
screening of 19 individual yeast reductases for their effciency and enantioselectivity, overview |
Saccharomyces cerevisiae |
4-hydroxyazetidine-2,3-diyl diacetate + NADP+ |
stereochemistry of products of the different enzymes, detailed overview |
? |
|
Subunits
Subunits |
Comment |
Organism |
monomer |
- |
Saccharomyces cerevisiae |
Synonyms
Synonyms |
Comment |
Organism |
aldose reductase |
- |
Saccharomyces cerevisiae |
pH Optimum
pH Optimum Minimum |
pH Optimum Maximum |
Comment |
Organism |
7 |
8 |
assay at |
Saccharomyces cerevisiae |
Cofactor
Cofactor |
Comment |
Organism |
Structure |
NADPH |
- |
Saccharomyces cerevisiae |
|