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Literature summary for 1.1.1.21 extracted from

  • Ramana, K.V.; Bhatnagar, A.; Srivastava, S.; Yadav, U.C.; Awasthi, S.; Awasthi, Y.C.; Srivastava, S.K.
    Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth (2006), J. Biol. Chem., 281, 17652-17660.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxy-trans-2-nonenal i.e. HNE, a lipid peroxidation-derived aldehyde, triggers multiple signaling cascades that variably affect cell growth, differentiation, and apoptosis, the mitogenic effects of HNE, but not GS-HNE or GSDHN, are abolished by glutathione depletion Rattus norvegicus
glutathionyl-1,4-dihydroxynonene i.e. GS-DHN, the mitogenic effects of HNE, but not GS-HNE or GSDHN, are abolished by glutathione depletion, stimulates protein kinase C, NF-kappaB, and AP-1, and increases cell growth in vascular smooth muscle cells Rattus norvegicus
glutathionyl-4-hydroxynonenal i.e. GS-HNE, the mitogenic effects of HNE, but not GS-HNE or GSDHN, are abolished by glutathione depletion, stimulates protein kinase C, NF-kappaB, and AP-1, and increases cell growth in vascular smooth muscle cells Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
aorta vascular smooth muscle cells Rattus norvegicus
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smooth muscle vascular cells Rattus norvegicus
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