Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme inhibition by antisense ablation with siRNA prevents fibroblast growth factorinduced and platelet-derived growth factorinduced up-regulation of PGE2 synthesis in Caco-2 cells, overview, nude mice bearing SW480 human colon adenocarcinoma cells completely arrest tumor progression | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sorbinil | enzyme inhibition abolishes fibroblast growth factorinduced and platelet-derived growth factorinduced up-regulation of PGE2 synthesis and lipid-adehyde signaling, e.g. by 4-hydroxy-trans-2-nonenal, in Caco-2 cells, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme reduces toxic lipid aldehydes and their conjugates with glutathione, besides reducing aldo-sugars efficiently, inhibition of AR prevents growth factor-induced COX-2 activity, reduces COX-2 protein and mRNA, and significantly decreases activation of nuclear factor-KB and protein kinase C, and phosphorylation of PKC-B2 as well as progression of Caco-2 cell growth but has no effect on COX-1 activity, reduces PGE2 synthesis and lipid-adehyde signaling, e.g. by 4-hydroxy-trans-2-nonenal, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | colon cancer cell line | Homo sapiens | - |
HCT-116 cell | colon cancer cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme reduces toxic lipid aldehydes and their conjugates with glutathione, besides reducing aldo-sugars efficiently, inhibition of AR prevents growth factor-induced COX-2 activity, reduces COX-2 protein and mRNA, and significantly decreases activation of nuclear factor-KB and protein kinase C, and phosphorylation of PKC-B2 as well as progression of Caco-2 cell growth but has no effect on COX-1 activity, reduces PGE2 synthesis and lipid-adehyde signaling, e.g. by 4-hydroxy-trans-2-nonenal, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |