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Literature summary for 1.1.1.21 extracted from
- Upregulation of aldose reductase by homocysteine in type II alveolar epithelial cells (2005), Biochem. Biophys. Res. Commun., 337, 1084-1091.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | upregulation of the enzyme by homocysteine in type II alveolar epithelial cells, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aldose + NADPH + H+ | Homo sapiens | upregulation of the enzyme by homocysteine in type II alveolar epithelial cells can lead to cell damage and pulmonary disease, overview | alditol + NADP+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P15121 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | type II alveolar epithelial cell line, AR expression analysis | Homo sapiens | - |
| lung | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aldose + NADPH + H+ | - |
Homo sapiens | alditol + NADP+ | - |
? | |
| aldose + NADPH + H+ | upregulation of the enzyme by homocysteine in type II alveolar epithelial cells can lead to cell damage and pulmonary disease, overview | Homo sapiens | alditol + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AKR1B1 | - |
Homo sapiens |
| aldose reductase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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