Protein Variants | Comment | Organism |
---|---|---|
C298A/W219Y | protein data bank: 1az1, structural analysis by molecular dynamics simulations | Homo sapiens |
Y48H | protein data bank: 2acu, structural analysis by molecular dynamics simulations | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
IDD594 | - |
Homo sapiens | |
IDD594 | - |
Sus scrofa | |
sorbinil | - |
Homo sapiens | |
sorbinil | - |
Sus scrofa | |
Tolrestat | - |
Homo sapiens | |
Tolrestat | - |
Sus scrofa | |
Zenarestat | - |
Homo sapiens | |
Zenarestat | - |
Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Sus scrofa | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
More | structural analysis by molecular dynamics simulations, highly conserved confomations around the catalytic site with H110-Y48-NADP+ orientation stabilized by a water molecule | Homo sapiens |
More | structural analysis by molecular dynamics simulations, highly conserved confomations around the catalytic site with H110-Y48-NADP+ orientation stabilized by a water molecule | Sus scrofa |