Literature summary for 1.1.1.21 extracted from

Chang, K.C.; Paek, K.S.; Kim, H.J.; Lee, Y.S.; Yabe-Nishimura, C.; Seo, H.G.
Substrate-induced up-regulation of aldose reductase by methylglyoxal, a reactive oxoaldehyde elevated in diabetes (2002), Mol. Pharmacol., 61, 1184-1191.

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Activating Compound

Activating Compound	Comment	Organism	Structure
methylglyoxal	up to 4.5fold induction of mRNA, activity and protein level, abolished in presence of cycloheximide or actinomycin D	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	protective role of enzyme against methylglyoxal induced cell damage	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
muscle	aortic smooth muscle cell	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	protective role of enzyme against methylglyoxal induced cell damage	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)