Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.21 extracted from

  • Galvez, A.S.; Ulloa, J.A.; Chiong, M.; Criollo, A.; Eisner, V.; Barros, L.F.; Lavandero, S.
    Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol (2003), J. Biol. Chem., 278, 38484-38494.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
sorbitol 600 mosmol per kg H2O, up to 2fold increase in activity Rattus norvegicus
SP-600125 0.01 mM, about 50% increase of sorbitol-induced activity Rattus norvegicus

Application

Application Comment Organism
medicine inhibition of enzyme by zolrestat attenuates apoptosis in sorbitol-treated cells. Hyperosmolarity-induced cell death requires induction of enzyme as well as a decrease in intracellular glutathione levels Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Ly-294002 0.05 mM, little decrease in sorbitol-induced activity Rattus norvegicus
PD-98059 0.05 mM, decrease of sorbitol-induced activity to control level Rattus norvegicus
SB-203580 0 0.01 mM, decrease of sorbitol-induced activity below control level Rattus norvegicus
zopolrestat
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart cultured cardiomyocyte Rattus norvegicus
-